纯度:>98% TLC
分子式:C27H31NO3S2
分子量:481.67
溶剂:DMSO (>25 mg/mL)
性状:Off-white solid
存储:-20°C
Activity (short version):PTP1B inhibitor
Function / Pharmacology:KY-226 (CAS 1621673-53-7) is a selective allosteric protein tyrosine phosphatase 1B (PTP1B) inhibitor (IC50 = 250 nM) with no activity at PPARγ.1 It significantly reduced plasma glucose, triglyceride, and A1c levels without weight gain in db/db mice.2 It has been suggested that KY-226’s anti-diabetic effects occur via enhancements in insulin signaling and anti-obesity effects via leptin signaling enhancements.2 KY-226 has also been shown to protect neurons from cerebral ischemia.3 This effect is mediated by restoration of tight junction proteins via activation of the Akt/FoxO1 pathway.4