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Grapiprant
- 英文名称:Grapiprant
- 品牌:WYTSCI
- 产地:进口
- 型号:1MG
- 货号:WT-AY-B11054
- cas:415903-37-6
- 价格: ¥1/mg
- 发布日期: 2025-04-10
- 更新日期: 2025-05-23
产品详请
产地 | 进口 |
品牌 | WYTSCI |
货号 | WT-AY-B11054 |
用途 | 科研检测 |
英文名称 | Grapiprant |
包装规格 | 1MG |
CAS编号 | 415903-37-6 |
别名 | Grapiprant |
纯度 | 98+% |
分子式 | |
是否进口 | 是 |
纯度:98% by TLC;NMR (Conforms)
分子式:C26H29N5O3S
分子量:491.61
溶剂:DMSO (>10 mg/ml)
性状:Off-white solid
存储:-20°C
Activity (short version):EP4 receptor antagonist.
Function / Pharmacology:Grapiprant (415903-37-6) is a potent (Ki = 13 nM for human and 20 nM for rat) and selective prostaglandin EP4 receptor antagonist.1 It produces antihyperalgesic effects in animal models of pain, and has significant anti-inflammatory effects in a rat model of adjuvant-induced arthritis.2 EP4 receptors have been shown to be involved in PGE2 stimulation of Th1 differentiation and Th17 expansion revealing a potential role for PGE2 receptors in immunosuppression.3,4 Grapiprant/Pembrolizumab combination is in clinical trials for advanced or metastatic NSCLC adenocarcinoma.5
分子式:C26H29N5O3S
分子量:491.61
溶剂:DMSO (>10 mg/ml)
性状:Off-white solid
存储:-20°C
Activity (short version):EP4 receptor antagonist.
Function / Pharmacology:Grapiprant (415903-37-6) is a potent (Ki = 13 nM for human and 20 nM for rat) and selective prostaglandin EP4 receptor antagonist.1 It produces antihyperalgesic effects in animal models of pain, and has significant anti-inflammatory effects in a rat model of adjuvant-induced arthritis.2 EP4 receptors have been shown to be involved in PGE2 stimulation of Th1 differentiation and Th17 expansion revealing a potential role for PGE2 receptors in immunosuppression.3,4 Grapiprant/Pembrolizumab combination is in clinical trials for advanced or metastatic NSCLC adenocarcinoma.5