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SR0987
- 英文名称:SR0987
- 品牌:WYTSCI
- 产地:进口
- 型号:1MG
- 货号:WT-AY-B11056
- cas:303126-97-8
- 价格: ¥1/mg
- 发布日期: 2025-04-10
- 更新日期: 2025-05-23
产品详请
产地 | 进口 |
品牌 | WYTSCI |
货号 | WT-AY-B11056 |
用途 | 科研检测 |
英文名称 | SR0987 |
包装规格 | 1MG |
CAS编号 | 303126-97-8 |
别名 | SR0987 |
纯度 | 98+% |
分子式 | |
是否进口 | 是 |
纯度:98% by HPLC;NMR (Conforms)
分子式:C16H10F6NO2
分子量:397.70
溶剂:DMSO (>25 mg/ml), Ethanol (>25 mg/ml)
性状:White solid
存储:-20°C
Activity (short version):RORγt agonist
Function / Pharmacology:RORγt is a T cell specific isoform of ROR that is a key transcription factor for initiating the differentiation of Th17 and Tc17 cells. SR0987 (303126-97-8) is a RORγt agonist that drives proliferation of Th17 cells and decrease levels of the immune checkpoint protein PD-1. In a Ga14 UAS-Luc cotransfection system, SR0987 induced reporter gene expression (EC50 = 800nM). Treatment of human Jurkat T cells with SR0987 resulted in decreased cell surface PD-1 expression. RORγt agonists may synergize with current anti-PD-1 therapy and represent a new potential class of cancer immunotherapeutic.
分子式:C16H10F6NO2
分子量:397.70
溶剂:DMSO (>25 mg/ml), Ethanol (>25 mg/ml)
性状:White solid
存储:-20°C
Activity (short version):RORγt agonist
Function / Pharmacology:RORγt is a T cell specific isoform of ROR that is a key transcription factor for initiating the differentiation of Th17 and Tc17 cells. SR0987 (303126-97-8) is a RORγt agonist that drives proliferation of Th17 cells and decrease levels of the immune checkpoint protein PD-1. In a Ga14 UAS-Luc cotransfection system, SR0987 induced reporter gene expression (EC50 = 800nM). Treatment of human Jurkat T cells with SR0987 resulted in decreased cell surface PD-1 expression. RORγt agonists may synergize with current anti-PD-1 therapy and represent a new potential class of cancer immunotherapeutic.