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Selinexor
- 英文名称:Selinexor
- 品牌:WYTSCI
- 产地:进口
- 型号:1MG
- 货号:WT-AY-B11059
- cas:1393477-72-9
- 价格: ¥1/mg
- 发布日期: 2025-04-10
- 更新日期: 2025-05-23
产品详请
产地 | 进口 |
品牌 | WYTSCI |
货号 | WT-AY-B11059 |
用途 | 科研检测 |
英文名称 | Selinexor |
包装规格 | 1MG |
CAS编号 | 1393477-72-9 |
别名 | Selinexor |
纯度 | 98+% |
分子式 | |
是否进口 | 是 |
纯度:98% by TLC;NMR (Conforms)
分子式:C17H11F6N7O
分子量:443.31
溶剂:DMSO (>25 mg/ml) Ethanol (>25 mg/ml)
性状:Off-white solid
存储:-20°C
Activity (short version):CRM1/XPO1 nuclear export receptor inhibitor
Function / Pharmacology:Selinexor is a potent inhibitor of the nuclear export receptor, chromosome region maintenance 1 (CRM1; Exportin-1 (XPO1)). It exhibited potent growth suppression in various T-cell acute lymphoblastic leukemia (T-ALL) cells (IC50’s = 34-203 nM)1 and pancreatic cancer cells (IC50 ~ 150 nM)2. Selinexor is being investigated as a possible chemotherapeutic in treating multiple types of cancer.3-8 Currently in clinical trials.
分子式:C17H11F6N7O
分子量:443.31
溶剂:DMSO (>25 mg/ml) Ethanol (>25 mg/ml)
性状:Off-white solid
存储:-20°C
Activity (short version):CRM1/XPO1 nuclear export receptor inhibitor
Function / Pharmacology:Selinexor is a potent inhibitor of the nuclear export receptor, chromosome region maintenance 1 (CRM1; Exportin-1 (XPO1)). It exhibited potent growth suppression in various T-cell acute lymphoblastic leukemia (T-ALL) cells (IC50’s = 34-203 nM)1 and pancreatic cancer cells (IC50 ~ 150 nM)2. Selinexor is being investigated as a possible chemotherapeutic in treating multiple types of cancer.3-8 Currently in clinical trials.