纯度:98% by HPLC,;NMR (Conforms)
分子式:C22H36O3
分子量:348.52
溶剂:DMSO (>25 mg/ml) Ethanol (15 mg/ml)
性状:White solid
存储:-20°C
Activity (short version):HAT inhibitor
Function / Pharmacology:Anacardic acid is a natural product found in cashew nut oil. It is an inhibitor of the histone acetyltransferases p300 and PCAF (IC50’s = 8.5 and 5.0 μM respectively).1 Anacardic acid sensitizes cancer cells to ionizing radiation2 and suppresses proteins involved in invasion and angiogenesis (Src/FAK/Rho GTPases3 and MMP’s 2 (IC50 = 11.11 μM)4 and 9). It inhibits both inducible and constitutive NF-κB activation.5