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A-196
- 英文名称：A-196
- 品牌：WYTSCI
- 产地：进口
- 型号：1MG
- 货号：WT-AY-B11066
- cas：1982372-88-2
- 价格： ￥1/mg
- 发布日期： 2025-04-10
- 更新日期： 2025-11-03
产品详请
| 产地 | 进口 |
| 品牌 | WYTSCI |
| 货号 | WT-AY-B11066 |
| 用途 | 科研检测 |
| 英文名称 | A-196 |
| 包装规格 | 1MG |
| CAS编号 | 1982372-88-2 |
| 别名 | A-196 |
| 纯度 | 98+% |
| 分子式 | |
| 是否进口 | 是 |
纯度:98% by TLC;NMR (Conforms)
分子式:C18H16Cl2N4
分子量:359.25
溶剂:DMSO (5 mg/ml)
性状:White solid
存储:-20°C
Activity (short version):SUV420H1/H2 lysine methyltransferase inhibitor
Function / Pharmacology:A-196 (1982372-88-2) is a potent and selective (over 29 other methyltransferases) inhibitor of the protein lysine methyltransferases SUV420H1(IC50 = 25 nM) and SUV420H2 (IC50 = 144 nM). It substantially inhibited non-homologous end-joining (NHEJ)-directed DNA repair but not homology-directed repair(HDR) in cells treated with ionizing radiation. A-196 is active in cells and displayed no toxicity in several cell lines.
分子式:C18H16Cl2N4
分子量:359.25
溶剂:DMSO (5 mg/ml)
性状:White solid
存储:-20°C
Activity (short version):SUV420H1/H2 lysine methyltransferase inhibitor
Function / Pharmacology:A-196 (1982372-88-2) is a potent and selective (over 29 other methyltransferases) inhibitor of the protein lysine methyltransferases SUV420H1(IC50 = 25 nM) and SUV420H2 (IC50 = 144 nM). It substantially inhibited non-homologous end-joining (NHEJ)-directed DNA repair but not homology-directed repair(HDR) in cells treated with ionizing radiation. A-196 is active in cells and displayed no toxicity in several cell lines.
