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A-196
- 英文名称:A-196
- 品牌:WYTSCI
- 产地:进口
- 型号:1MG
- 货号:WT-AY-B11066
- cas:1982372-88-2
- 价格: ¥1/mg
- 发布日期: 2025-04-10
- 更新日期: 2025-05-23
产品详请
产地 | 进口 |
品牌 | WYTSCI |
货号 | WT-AY-B11066 |
用途 | 科研检测 |
英文名称 | A-196 |
包装规格 | 1MG |
CAS编号 | 1982372-88-2 |
别名 | A-196 |
纯度 | 98+% |
分子式 | |
是否进口 | 是 |
纯度:98% by TLC;NMR (Conforms)
分子式:C18H16Cl2N4
分子量:359.25
溶剂:DMSO (5 mg/ml)
性状:White solid
存储:-20°C
Activity (short version):SUV420H1/H2 lysine methyltransferase inhibitor
Function / Pharmacology:A-196 (1982372-88-2) is a potent and selective (over 29 other methyltransferases) inhibitor of the protein lysine methyltransferases SUV420H1(IC50 = 25 nM) and SUV420H2 (IC50 = 144 nM). It substantially inhibited non-homologous end-joining (NHEJ)-directed DNA repair but not homology-directed repair(HDR) in cells treated with ionizing radiation. A-196 is active in cells and displayed no toxicity in several cell lines.
分子式:C18H16Cl2N4
分子量:359.25
溶剂:DMSO (5 mg/ml)
性状:White solid
存储:-20°C
Activity (short version):SUV420H1/H2 lysine methyltransferase inhibitor
Function / Pharmacology:A-196 (1982372-88-2) is a potent and selective (over 29 other methyltransferases) inhibitor of the protein lysine methyltransferases SUV420H1(IC50 = 25 nM) and SUV420H2 (IC50 = 144 nM). It substantially inhibited non-homologous end-joining (NHEJ)-directed DNA repair but not homology-directed repair(HDR) in cells treated with ionizing radiation. A-196 is active in cells and displayed no toxicity in several cell lines.