纯度:98% by HPLC,;NMR (Conforms)
分子式:C19H20ClN3O5S
分子量:437.9
溶剂:DMSO (>25 mg/ml)
性状:White solid
存储:-20°C
Activity (short version):LSD1 inhibitor
Function / Pharmacology:Potent (IC50 = 13 nM) and reversible inhibitor of the histone demethylase LSD1 (KDM1A).1 It is inactive against the closely related flavin enzymes MAO A,B as well as lactate dehydrogenase, several CYP’s and hERG. LSD1 regulates the balance between self-renewal and differentiation of stem cells and is highly expressed in various cancers.2-6 SP2509 promotes autophagy in neuroblastoma cells.7