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PTC-209
- 英文名称:PTC-209
- 品牌:WYTSCI
- 产地:进口
- 型号:1MG
- 货号:WT-AY-B11070
- cas:315704-66-6
- 价格: ¥1/mg
- 发布日期: 2025-04-10
- 更新日期: 2025-05-23
产品详请
产地 | 进口 |
品牌 | WYTSCI |
货号 | WT-AY-B11070 |
用途 | 科研检测 |
英文名称 | PTC-209 |
包装规格 | 1MG |
CAS编号 | 315704-66-6 |
别名 | PTC-209 |
纯度 | 98+% |
分子式 | |
是否进口 | 是 |
纯度:98% by HPLC ,;NMR (Conforms)
分子式:C17H13Br2N5OS
分子量:495.19
溶剂:DMSO (>25 mg/ml)
性状:Yellow solid
存储:-20°C
Activity (short version):BMI-1 inhibitor
Function / Pharmacology:An inhibitor of BMI-1 (IC50 = 500 nM), part of the polycomb repressive complex 1 (PCR1).1 It inhibited endogenous BMI-1 expression in human colorectal HCT116 and human fibrosarcoma HT1080 tumor cells resulting in reduced tumor volume as well as reduced cancer initiating cell (CIC) number. PTC-209 displayed potent in vivo antitumor effects in several cancer models including breast2, head and neck3, glioblastoma4, prostate5, colon5, and rhabdomyosarcoma6. It also promoted chemically-induced direct cardiac reprogramming of cardiac fibroblasts into cardiac myocytes.7,8
分子式:C17H13Br2N5OS
分子量:495.19
溶剂:DMSO (>25 mg/ml)
性状:Yellow solid
存储:-20°C
Activity (short version):BMI-1 inhibitor
Function / Pharmacology:An inhibitor of BMI-1 (IC50 = 500 nM), part of the polycomb repressive complex 1 (PCR1).1 It inhibited endogenous BMI-1 expression in human colorectal HCT116 and human fibrosarcoma HT1080 tumor cells resulting in reduced tumor volume as well as reduced cancer initiating cell (CIC) number. PTC-209 displayed potent in vivo antitumor effects in several cancer models including breast2, head and neck3, glioblastoma4, prostate5, colon5, and rhabdomyosarcoma6. It also promoted chemically-induced direct cardiac reprogramming of cardiac fibroblasts into cardiac myocytes.7,8