纯度:98% by HPLC ,;NMR (Conforms)
分子式:C17H13Br2N5OS
分子量:495.19
溶剂:DMSO (>25 mg/ml)
性状:Yellow solid
存储:-20°C
Activity (short version):BMI-1 inhibitor
Function / Pharmacology:An inhibitor of BMI-1 (IC50 = 500 nM), part of the polycomb repressive complex 1 (PCR1).1 It inhibited endogenous BMI-1 expression in human colorectal HCT116 and human fibrosarcoma HT1080 tumor cells resulting in reduced tumor volume as well as reduced cancer initiating cell (CIC) number. PTC-209 displayed potent in vivo antitumor effects in several cancer models including breast2, head and neck3, glioblastoma4, prostate5, colon5, and rhabdomyosarcoma6. It also promoted chemically-induced direct cardiac reprogramming of cardiac fibroblasts into cardiac myocytes.7,8