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iBAP-II
- 英文名称：iBAP-II
- 品牌：WYTSCI
- 产地：进口
- 型号：1MG
- 货号：WT-AY-B11083
- cas：1013813-81-4
- 价格： ￥1/mg
- 发布日期： 2025-04-10
- 更新日期： 2025-05-23
产品详请
| 产地 | 进口 |
| 品牌 | WYTSCI |
| 货号 | WT-AY-B11083 |
| 用途 | 科研检测 |
| 英文名称 | iBAP-II |
| 包装规格 | 1MG |
| CAS编号 | 1013813-81-4 |
| 别名 | iBAP-II |
| 纯度 | 98+% |
| 分子式 | |
| 是否进口 | 是 |
纯度:>98% by HPLC;NMR (Conforms)
分子式:C18H16N2O3
分子量:308.33
溶剂:DMSO (25 mg/ml)
性状:Yellow solid
存储:-20°C
Activity (short version):BAP1 deubiquitinase inhibitor
Function / Pharmacology:Inhibitor of the H2AK119 deubiquitinase BAP1 (IC50 = 0.092 μg/ml). It is selective for BAP1 over UCHL5, USP5,7,8, TNFAIP3-catalytic domain, USP2-catalytic domain, Otubain-1, and Ataxin3. iBAP-II disrupted the BAP1/ASXL3/BRD4 axis via induction of protein degradation of the ASXL3 scaffold protein in the small cell lung cancer lines NCI-H1963, NCI-H748, and NCI-H1882. It also suppressed expression of the master transcription factor ASCL1 in NCI-H1963 small cell lung cancer cells. iBAP-II significantly delayed disease progression in a small cell lung cancer xenograft mouse model.
分子式:C18H16N2O3
分子量:308.33
溶剂:DMSO (25 mg/ml)
性状:Yellow solid
存储:-20°C
Activity (short version):BAP1 deubiquitinase inhibitor
Function / Pharmacology:Inhibitor of the H2AK119 deubiquitinase BAP1 (IC50 = 0.092 μg/ml). It is selective for BAP1 over UCHL5, USP5,7,8, TNFAIP3-catalytic domain, USP2-catalytic domain, Otubain-1, and Ataxin3. iBAP-II disrupted the BAP1/ASXL3/BRD4 axis via induction of protein degradation of the ASXL3 scaffold protein in the small cell lung cancer lines NCI-H1963, NCI-H748, and NCI-H1882. It also suppressed expression of the master transcription factor ASCL1 in NCI-H1963 small cell lung cancer cells. iBAP-II significantly delayed disease progression in a small cell lung cancer xenograft mouse model.
