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TETi76 ester
- 英文名称:TETi76 ester
- 品牌:WYTSCI
- 产地:进口
- 型号:1MG
- 货号:WT-AY-B11085
- cas:1451750-73-4
- 价格: ¥1/mg
- 发布日期: 2025-04-10
- 更新日期: 2025-05-16
产品详请
产地 | 进口 |
品牌 | WYTSCI |
货号 | WT-AY-B11085 |
用途 | 科研检测 |
英文名称 | TETi76 ester |
包装规格 | 1MG |
CAS编号 | 1451750-73-4 |
别名 | TETi76 ester |
纯度 | 98+% |
分子式 | |
是否进口 | 是 |
纯度:>98% TLC,;NMR (Conforms)
分子式:C10H16O5
分子量:216.23
溶剂:DMSO (100 mg/ml)
性状:Colorless oil
存储:-20°C
Activity (short version):TET inhibitor
Function / Pharmacology:Cell permeable inhibitor of TET dioxygenases (IC50s: TET1 = 1.5 μM; TET2 = 9.4 μM; TET3 = 8.8 μM), indirect (via cytosine hydroxymethylation) erasers of DNA methylation.1,2 TET2 is frequently mutated in myeloid neoplasms – TET2 inhibition with TETi76 restricted clonal outgrowth and induced apoptosis of TET2 mutants but not normal hematopoietic precursor cells in vitro and in vivo.
分子式:C10H16O5
分子量:216.23
溶剂:DMSO (100 mg/ml)
性状:Colorless oil
存储:-20°C
Activity (short version):TET inhibitor
Function / Pharmacology:Cell permeable inhibitor of TET dioxygenases (IC50s: TET1 = 1.5 μM; TET2 = 9.4 μM; TET3 = 8.8 μM), indirect (via cytosine hydroxymethylation) erasers of DNA methylation.1,2 TET2 is frequently mutated in myeloid neoplasms – TET2 inhibition with TETi76 restricted clonal outgrowth and induced apoptosis of TET2 mutants but not normal hematopoietic precursor cells in vitro and in vivo.