纯度:>98% by HPLC;NMR (Conforms)
分子式:C21H22N4O6S
分子量:458.49
溶剂:DMSO (>25 mg/ml)
性状:Pale yellow solid
存储:-20°C
Activity (short version):Thymidylate synthase inhibitor
Function / Pharmacology:Raltitrexed is an inhibitor of thymidylate synthase with significantly increased potency in many cancer cell lines when compared with 5-fluorouracil.1,2 It is also an inhibitor of the methyltransferase G9a (IC50 = 120 nM) and decreased A? aggregates in C. elegans indicating therapeutic potential for the treatment of Alzheimer’s disease.3