纯度:98% by HPLC;NMR (Conforms)
分子式:C13H9Cl2N5 HCl
分子量:342.61
溶剂:DMSO (>25 mg/ml)
性状:White or off-white solid
存储:-20°C
Activity (short version):P2X7 antagonist
Function / Pharmacology:A-438079 (899431-18-6) is a competitive P2X7 receptor antagonist (pIC50 = 6.9).1 Displayed antinociceptive effects in a rat model of neuropathic pain.2? A-438079 prevented the LPS-induced release of IL-1? and attenuated LPS-induced (via intrathecal lumbar injection) mechanical hyperalgesia in rat hindpaws.3? It prevented mechanical hyperalgesia following peripheral nerve injury.4 A-438079 protected against cerebral ischemia/reperfusion injury in a rat model via reduction of the neuroinflammatory response.5