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SR3335
- 英文名称：SR3335
- 品牌：WYTSCI
- 产地：进口
- 型号：1MG
- 货号：WT-AY-B11097
- cas：293753-05-6
- 价格： ￥1/mg
- 发布日期： 2025-04-10
- 更新日期： 2025-05-23
产品详请
| 产地 | 进口 |
| 品牌 | WYTSCI |
| 货号 | WT-AY-B11097 |
| 用途 | 科研检测 |
| 英文名称 | SR3335 |
| 包装规格 | 1MG |
| CAS编号 | 293753-05-6 |
| 别名 | SR3335 |
| 纯度 | 98+% |
| 分子式 | |
| 是否进口 | 是 |
纯度:>98% by HPLC;NMR (Conforms)
分子式:C13H9F6NO3S2
分子量:405.33
溶剂:DMSO (>50 mg/ml)
性状:White solid
存储:-20°C
Activity (short version):RORα partial inverse agonist
Function / Pharmacology:SR3335 (293753-05-6) is a selective RORα partial inverse agonist (IC50 = 480 nM) – displays no activity at ROR?, RORγ, or FXR.1 It was able to suppress gluconeogenesis in diet-induced obese mice. SR3335 was able to upregulate uncoupling protein 1 (UCP1), a unique mitochondrial protein devoted to thermogenesis, in wild type mice leading to decreased body weight and fat mass.2,3 It inhibited the development of mouse and human TH17 cells in vitro and in vivo leaving thymic T cells intact.4 SR3335’s ability to block pathogenic, but not protective TH17 cell function makes it an important new tool in the study of TH17-mediated inflammatory and autoimmune diseases.
分子式:C13H9F6NO3S2
分子量:405.33
溶剂:DMSO (>50 mg/ml)
性状:White solid
存储:-20°C
Activity (short version):RORα partial inverse agonist
Function / Pharmacology:SR3335 (293753-05-6) is a selective RORα partial inverse agonist (IC50 = 480 nM) – displays no activity at ROR?, RORγ, or FXR.1 It was able to suppress gluconeogenesis in diet-induced obese mice. SR3335 was able to upregulate uncoupling protein 1 (UCP1), a unique mitochondrial protein devoted to thermogenesis, in wild type mice leading to decreased body weight and fat mass.2,3 It inhibited the development of mouse and human TH17 cells in vitro and in vivo leaving thymic T cells intact.4 SR3335’s ability to block pathogenic, but not protective TH17 cell function makes it an important new tool in the study of TH17-mediated inflammatory and autoimmune diseases.
