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ML277
- 英文名称：ML277
- 品牌：WYTSCI
- 产地：进口
- 型号：1MG
- 货号：WT-AY-B11098
- cas：1401242-74-7
- 价格： ￥1/mg
- 发布日期： 2025-04-10
- 更新日期： 2025-05-12
产品详请
| 产地 | 进口 |
| 品牌 | WYTSCI |
| 货号 | WT-AY-B11098 |
| 用途 | 科研检测 |
| 英文名称 | ML277 |
| 包装规格 | 1MG |
| CAS编号 | 1401242-74-7 |
| 别名 | ML277 |
| 纯度 | 98+% |
| 分子式 | |
| 是否进口 | 是 |
纯度:>98% by HPLC;NMR (Conforms)
分子式:C23H25N3O4S2
分子量:471.59
溶剂:DMSO (20 mg/ml)
性状:White solid
存储:-20°C
Activity (short version):Potent Kv7.1 activator
Function / Pharmacology:ML277 is a potent (EC50 = 260 nM) activator of Kv7.1 with selectivity against Kv7.2, Kv7.4, and Kv11.1 (hERG).1 ML277 enhances cardiac delayed rectifier K+ currents (IKs) in human iPSC-derived cardiomyocytes from normal and long QT-interval syndrome afflicted patients suggesting potential therapeutic use in long QT-interval syndrome.2,3 It displayed cardioprotective effects against ischemia in cellular and whole-heart models.4
分子式:C23H25N3O4S2
分子量:471.59
溶剂:DMSO (20 mg/ml)
性状:White solid
存储:-20°C
Activity (short version):Potent Kv7.1 activator
Function / Pharmacology:ML277 is a potent (EC50 = 260 nM) activator of Kv7.1 with selectivity against Kv7.2, Kv7.4, and Kv11.1 (hERG).1 ML277 enhances cardiac delayed rectifier K+ currents (IKs) in human iPSC-derived cardiomyocytes from normal and long QT-interval syndrome afflicted patients suggesting potential therapeutic use in long QT-interval syndrome.2,3 It displayed cardioprotective effects against ischemia in cellular and whole-heart models.4
