纯度:>98% TLC,;NMR (Conforms)
分子式:C20H13NO3
分子量:315.33
溶剂:DMSO (15 mg/ml)
性状:Yellow solid
存储:-20°C
Activity (short version):IP6K inhibitor
Function / Pharmacology:Potent inhibitor of inositol hexakisphosphate kinase (IP6K) – the isoform IP3K1 regulates metabolism, promotes insulin secretion from ? cells, attenuates certain aspects of insulin signaling, and reduces whole-body energy expenditure by inhibiting adipocyte thermogenesis, thus making it an attractive target for treatment of obesity and obesity-induced metabolic dysfunction. It is selective for IP6K1 and 2 over IP6K3 (IC50s = 8.9 nM, 4.9 nM, and 1320 nM respectively). EC50 = 1.0 μM and 0.24 μM at 3hr and 18 hr respectively in intact HCT116 cells ([33]P-Pi efflux). Selective against a panel of 30 protein kinases and 5 CYP isoforms. UNC7467 improved glycemic profiles, ameliorated hepatic steatosis, and reduced weight gain without altering food intake in diet-induced obese mice.