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UNC7467
- 英文名称:UNC7467
- 品牌:WYTSCI
- 产地:进口
- 型号:1MG
- 货号:WT-AY-B11101
- cas:2922283-43-8
- 价格: ¥1/mg
- 发布日期: 2025-04-10
- 更新日期: 2025-05-23
产品详请
产地 | 进口 |
品牌 | WYTSCI |
货号 | WT-AY-B11101 |
用途 | 科研检测 |
英文名称 | UNC7467 |
包装规格 | 1MG |
CAS编号 | 2922283-43-8 |
别名 | UNC7467 |
纯度 | 98+% |
分子式 | |
是否进口 | 是 |
纯度:>98% TLC,;NMR (Conforms)
分子式:C20H13NO3
分子量:315.33
溶剂:DMSO (15 mg/ml)
性状:Yellow solid
存储:-20°C
Activity (short version):IP6K inhibitor
Function / Pharmacology:Potent inhibitor of inositol hexakisphosphate kinase (IP6K) – the isoform IP3K1 regulates metabolism, promotes insulin secretion from ? cells, attenuates certain aspects of insulin signaling, and reduces whole-body energy expenditure by inhibiting adipocyte thermogenesis, thus making it an attractive target for treatment of obesity and obesity-induced metabolic dysfunction. It is selective for IP6K1 and 2 over IP6K3 (IC50s = 8.9 nM, 4.9 nM, and 1320 nM respectively). EC50 = 1.0 μM and 0.24 μM at 3hr and 18 hr respectively in intact HCT116 cells ([33]P-Pi efflux). Selective against a panel of 30 protein kinases and 5 CYP isoforms. UNC7467 improved glycemic profiles, ameliorated hepatic steatosis, and reduced weight gain without altering food intake in diet-induced obese mice.
分子式:C20H13NO3
分子量:315.33
溶剂:DMSO (15 mg/ml)
性状:Yellow solid
存储:-20°C
Activity (short version):IP6K inhibitor
Function / Pharmacology:Potent inhibitor of inositol hexakisphosphate kinase (IP6K) – the isoform IP3K1 regulates metabolism, promotes insulin secretion from ? cells, attenuates certain aspects of insulin signaling, and reduces whole-body energy expenditure by inhibiting adipocyte thermogenesis, thus making it an attractive target for treatment of obesity and obesity-induced metabolic dysfunction. It is selective for IP6K1 and 2 over IP6K3 (IC50s = 8.9 nM, 4.9 nM, and 1320 nM respectively). EC50 = 1.0 μM and 0.24 μM at 3hr and 18 hr respectively in intact HCT116 cells ([33]P-Pi efflux). Selective against a panel of 30 protein kinases and 5 CYP isoforms. UNC7467 improved glycemic profiles, ameliorated hepatic steatosis, and reduced weight gain without altering food intake in diet-induced obese mice.