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UNC7467
  • 英文名称:UNC7467
  • 品牌:WYTSCI
  • 产地:进口
  • 型号:1MG
  • 货号:WT-AY-B11101
  • cas:2922283-43-8
  • 价格: ¥1/mg
  • 发布日期: 2025-04-10
  • 更新日期: 2025-05-12
产品详请
产地 进口
品牌 WYTSCI
货号 WT-AY-B11101
用途 科研检测
英文名称 UNC7467
包装规格 1MG
CAS编号 2922283-43-8
别名 UNC7467
纯度 98+%
分子式
是否进口
纯度:>98% TLC,;NMR (Conforms)
分子式:C20H13NO3
分子量:315.33
溶剂:DMSO (15 mg/ml)
性状:Yellow solid
存储:-20°C
Activity (short version):IP6K inhibitor
Function / Pharmacology:Potent inhibitor of inositol hexakisphosphate kinase (IP6K) – the isoform IP3K1 regulates metabolism, promotes insulin secretion from ? cells, attenuates certain aspects of insulin signaling, and reduces whole-body energy expenditure by inhibiting adipocyte thermogenesis, thus making it an attractive target for treatment of obesity and obesity-induced metabolic dysfunction. It is selective for IP6K1 and 2 over IP6K3 (IC50s = 8.9 nM, 4.9 nM, and 1320 nM respectively). EC50 = 1.0 μM and 0.24 μM at 3hr and 18 hr respectively in intact HCT116 cells ([33]P-Pi efflux). Selective against a panel of 30 protein kinases and 5 CYP isoforms. UNC7467 improved glycemic profiles, ameliorated hepatic steatosis, and reduced weight gain without altering food intake in diet-induced obese mice.
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