![]() |
Serodolin
- 英文名称:Serodolin
- 品牌:WYTSCI
- 产地:进口
- 型号:1MG
- 货号:WT-AY-B11104
- cas:1814929-81-1
- 价格: ¥1/mg
- 发布日期: 2025-04-10
- 更新日期: 2025-05-16
产品详请
产地 | 进口 |
品牌 | WYTSCI |
货号 | WT-AY-B11104 |
用途 | 科研检测 |
英文名称 | Serodolin |
包装规格 | 1MG |
CAS编号 | 1814929-81-1 |
别名 | Serodolin |
纯度 | 98+% |
分子式 | |
是否进口 | 是 |
纯度:>98% by HPLC;NMR (Conforms)
分子式:C22H27FN4O
分子量:382.47
溶剂:DMSO (50 mg/ml)
性状:Off-white solid
存储:-20°C
Activity (short version):?-Arrestin-biased 5-HT7 antagonist
Function / Pharmacology:Serodolin is a potent dual antagonist of the serotonin receptors 5-HT7 (Ki = 6.2 nM; IC50 = 5.7 nM cAMP response) and 5-HT2A (Ki = 19 nM; IC50 = 110 nM IP1 response) with significant selectivity over 5-HT1A and 5-HT6.1 Serodolin has recently been found to act as a ?-arrestin-biased inverse agonist on Gs signaling while inducing ERK activation requiring c-SRS activation, a unique pharmacological profile among 5-HT7 ligands.2 It decreased hyperalgesia and pain sensation in response to inflammatory, thermal, and mechanical stimulation in a mouse model demonstrating the therapeutic potential of a ?-arrestin-biased ligand for pain relief. Blood-brain barrier permeable.
分子式:C22H27FN4O
分子量:382.47
溶剂:DMSO (50 mg/ml)
性状:Off-white solid
存储:-20°C
Activity (short version):?-Arrestin-biased 5-HT7 antagonist
Function / Pharmacology:Serodolin is a potent dual antagonist of the serotonin receptors 5-HT7 (Ki = 6.2 nM; IC50 = 5.7 nM cAMP response) and 5-HT2A (Ki = 19 nM; IC50 = 110 nM IP1 response) with significant selectivity over 5-HT1A and 5-HT6.1 Serodolin has recently been found to act as a ?-arrestin-biased inverse agonist on Gs signaling while inducing ERK activation requiring c-SRS activation, a unique pharmacological profile among 5-HT7 ligands.2 It decreased hyperalgesia and pain sensation in response to inflammatory, thermal, and mechanical stimulation in a mouse model demonstrating the therapeutic potential of a ?-arrestin-biased ligand for pain relief. Blood-brain barrier permeable.