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CPI-444
- 英文名称：CPI-444
- 品牌：WYTSCI
- 产地：进口
- 型号：1MG
- 货号：WT-AY-B11109
- cas：1202402-40-1
- 价格： ￥1/mg
- 发布日期： 2025-04-10
- 更新日期： 2025-05-12
产品详请
| 产地 | 进口 |
| 品牌 | WYTSCI |
| 货号 | WT-AY-B11109 |
| 用途 | 科研检测 |
| 英文名称 | CPI-444 |
| 包装规格 | 1MG |
| CAS编号 | 1202402-40-1 |
| 别名 | CPI-444 |
| 纯度 | 98+% |
| 分子式 | |
| 是否进口 | 是 |
纯度:98% by HPLC;NMR (Conforms)
分子式:C20H21N7O3
分子量:407.43
溶剂:DMSO (>25 mg/ml)
性状:Beige solid
存储:-20°C
Activity (short version):Adenosine A2A receptor antagonist
Function / Pharmacology:CPI-444 (1202402-40-1) is a potent (Ki = 3.54 nM) and selective adenosine A2A receptor antagonist. It blocked the induction of cAMP induced by NECA in HEK-293 cells with an IC50 = 17.03 nM. CPI-444 monotherapy or in combination with anti-PD-1, anti-PD-L1, and anti-CTLA-4 induced T-cell-mediated tumor responses, inhibited tumor growth, and enabled antitumor immune memory.1,2 Currently in clinical trials for multiple cancers.3
分子式:C20H21N7O3
分子量:407.43
溶剂:DMSO (>25 mg/ml)
性状:Beige solid
存储:-20°C
Activity (short version):Adenosine A2A receptor antagonist
Function / Pharmacology:CPI-444 (1202402-40-1) is a potent (Ki = 3.54 nM) and selective adenosine A2A receptor antagonist. It blocked the induction of cAMP induced by NECA in HEK-293 cells with an IC50 = 17.03 nM. CPI-444 monotherapy or in combination with anti-PD-1, anti-PD-L1, and anti-CTLA-4 induced T-cell-mediated tumor responses, inhibited tumor growth, and enabled antitumor immune memory.1,2 Currently in clinical trials for multiple cancers.3
