纯度:>98% by HPLC;NMR (Conforms)
分子式:C25H29N9O3
分子量:503.57
溶剂:DMSO (5 mg/ml with warming)
性状:Beige solid
存储:-20°C
Activity (short version):Adenosine A2A receptor antagonist
Function / Pharmacology:Preladenant is a potent (Ki = 1.1nM) and selective (>1000-fold over other adenosine receptors) adenosine A2A antagonist.1 It has shown efficacy in rodent and primate models of Parkinsons disease without inducing dyskinesias and displays antidepressant effects.1-3 It has been shown that activation of the adenosine A2A receptor blocks the activation of immune cells and increases the number of regulatory T-cells.4-6 Currently in clinical trials as combination therapy with pembrolizumab.7