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Preladenant
- 英文名称:Preladenant
- 品牌:WYTSCI
- 产地:进口
- 型号:1MG
- 货号:WT-AY-B11110
- cas:377727-87-2
- 价格: ¥1/mg
- 发布日期: 2025-04-10
- 更新日期: 2025-05-23
产品详请
产地 | 进口 |
品牌 | WYTSCI |
货号 | WT-AY-B11110 |
用途 | 科研检测 |
英文名称 | Preladenant |
包装规格 | 1MG |
CAS编号 | 377727-87-2 |
别名 | Preladenant |
纯度 | 98+% |
分子式 | |
是否进口 | 是 |
纯度:>98% by HPLC;NMR (Conforms)
分子式:C25H29N9O3
分子量:503.57
溶剂:DMSO (5 mg/ml with warming)
性状:Beige solid
存储:-20°C
Activity (short version):Adenosine A2A receptor antagonist
Function / Pharmacology:Preladenant is a potent (Ki = 1.1nM) and selective (>1000-fold over other adenosine receptors) adenosine A2A antagonist.1 It has shown efficacy in rodent and primate models of Parkinsons disease without inducing dyskinesias and displays antidepressant effects.1-3 It has been shown that activation of the adenosine A2A receptor blocks the activation of immune cells and increases the number of regulatory T-cells.4-6 Currently in clinical trials as combination therapy with pembrolizumab.7
分子式:C25H29N9O3
分子量:503.57
溶剂:DMSO (5 mg/ml with warming)
性状:Beige solid
存储:-20°C
Activity (short version):Adenosine A2A receptor antagonist
Function / Pharmacology:Preladenant is a potent (Ki = 1.1nM) and selective (>1000-fold over other adenosine receptors) adenosine A2A antagonist.1 It has shown efficacy in rodent and primate models of Parkinsons disease without inducing dyskinesias and displays antidepressant effects.1-3 It has been shown that activation of the adenosine A2A receptor blocks the activation of immune cells and increases the number of regulatory T-cells.4-6 Currently in clinical trials as combination therapy with pembrolizumab.7