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Galunisertib
- 英文名称:Galunisertib
- 品牌:WYTSCI
- 产地:进口
- 型号:1MG
- 货号:WT-AY-B11115
- cas:700874-72-2
- 价格: ¥1/mg
- 发布日期: 2025-04-10
- 更新日期: 2025-05-16
产品详请
产地 | 进口 |
品牌 | WYTSCI |
货号 | WT-AY-B11115 |
用途 | 科研检测 |
英文名称 | Galunisertib |
包装规格 | 1MG |
CAS编号 | 700874-72-2 |
别名 | Galunisertib |
纯度 | 98+% |
分子式 | |
是否进口 | 是 |
纯度:98%,;NMR (Conforms)
分子式:C22H19N5O
分子量:369.43
溶剂:DMSO (25 mg/ml)
性状:White solid
存储:-20°C
Activity (short version):TGF? receptor 1 inhibitor / Cancer immunotherapeutic
Function / Pharmacology:Galunisertib is a TGF-B kinase (ALK5) antagonist.1 It stimulated hematopoiesis from primary myelodysplastic syndrome bone marrow specimens via downregulation of SMAD2 phosphorylation.2 It has been in clinical trials for treatment of various cancers.3-5 Galunisertib has more recently been used to enhance the anti-neuroblastoma activity of anti-GD2 antibody Dinutuximab with natural killer cells6 and preserved the function of in vitro expanded natural killer cells in AML and colon cancer models7. Galunisertib reversed TGF? and regulatory T cell mediated suppression of human T cell proliferation. In combination with PD-L1 blockade, it resulted in improved tumor growth inhibition and complete regressions in colon carcinoma models.8
分子式:C22H19N5O
分子量:369.43
溶剂:DMSO (25 mg/ml)
性状:White solid
存储:-20°C
Activity (short version):TGF? receptor 1 inhibitor / Cancer immunotherapeutic
Function / Pharmacology:Galunisertib is a TGF-B kinase (ALK5) antagonist.1 It stimulated hematopoiesis from primary myelodysplastic syndrome bone marrow specimens via downregulation of SMAD2 phosphorylation.2 It has been in clinical trials for treatment of various cancers.3-5 Galunisertib has more recently been used to enhance the anti-neuroblastoma activity of anti-GD2 antibody Dinutuximab with natural killer cells6 and preserved the function of in vitro expanded natural killer cells in AML and colon cancer models7. Galunisertib reversed TGF? and regulatory T cell mediated suppression of human T cell proliferation. In combination with PD-L1 blockade, it resulted in improved tumor growth inhibition and complete regressions in colon carcinoma models.8