菜单 Close 公司首页 公司介绍 公司动态 证书荣誉 联系方式 在线留言
Bempedoic acid
  • 英文名称:Bempedoic acid
  • 品牌:WYTSCI
  • 产地:进口
  • 型号:1MG
  • 货号:WT-AY-B11116
  • cas:738606-46-7
  • 价格: ¥1/mg
  • 发布日期: 2025-04-10
  • 更新日期: 2025-05-12
产品详请
产地 进口
品牌 WYTSCI
货号 WT-AY-B11116
用途 科研检测
英文名称 Bempedoic acid
包装规格 1MG
CAS编号 738606-46-7
别名 Bempedoic acid
纯度 98+%
分子式
是否进口
纯度:>98% by TLC;NMR (Conforms)
分子式:C19H36O5
分子量:344.49
溶剂:DMSO (>25 mg/ml)
性状:White solid
存储:-20°C
Activity (short version):ATP citrate lyase inhibitor
Function / Pharmacology:Inhibitor of ATP citrate lyase (ACL) and activator of AMPK used in the treatment of hypercholesterolemia.1,2 In vivo, the active molecule is the CoA ester.2 Bempedoic acid requires activation by very long-chain acyl-CoA-synthetase (ACSVL1) – the absence of ACSVL1 in skeletal muscle provides a mechanistic basis for its use in statin-intolerant patients.3 LDL receptor upregulation, decreased LDL-C, and attenuation of atherosclerosis activities are independent of AMPK activation. It significantly cuts the risk of major cardiovascular events.4 Combination treatment of breast and pancreatic cancer cell lines with bempedoic acid and CDK4/6 inhibitors reduced cell growth and invasion.5 It displays anti-inflammatory activity possibly through both ACL inhibition6,7 and AMPK activation8.
联系方式
手机:15317051735
Q Q:
二维码扫描访问