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BI 2536
- 英文名称：BI 2536
- 品牌：WYTSCI
- 产地：进口
- 型号：1MG
- 货号：WT-AY-B11120
- cas：755038-02-9
- 价格： ￥1/mg
- 发布日期： 2025-04-10
- 更新日期： 2025-05-12
产品详请
| 产地 | 进口 |
| 品牌 | WYTSCI |
| 货号 | WT-AY-B11120 |
| 用途 | 科研检测 |
| 英文名称 | BI 2536 |
| 包装规格 | 1MG |
| CAS编号 | 755038-02-9 |
| 别名 | BI 2536 |
| 纯度 | 98+% |
| 分子式 | |
| 是否进口 | 是 |
纯度:97% by HPLC,;NMR (Conforms)
分子式:C28H39N7O3
分子量:521.67
溶剂:DMSO (20 mg/ml) Ethanol (>25 mg/ml)
性状:Off-white solid
存储:-20°C
Activity (short version):Dual Plk/BRD4 inhibitor - Destabilizes Myc
Function / Pharmacology:BI 2536 was originally reported as a potent (IC50’s Plk1 = 0.83nM, Plk2 = 3.5nM and Plk3 = 9.0nM) and selective2 Polo-like kinase inhibitor (IC50’s Plk1 = 0.83nM, Plk2 = 3.5nM and Plk3 = 9.0nM) that caused mitotic arrest and apoptosis induction in various human cancer cell lines.1 It was later found to be a potent inhibitor (IC50 = 100nM) of BET family member BRD4 and able to potently suppress c-Myc expression in MM.1S multiple myeloma cells.3 BI 2536 destabilizes N-Myc by inhibiting the deactivation of the ubiquitin E3 ligase Fbw7 by Plk1.4
分子式:C28H39N7O3
分子量:521.67
溶剂:DMSO (20 mg/ml) Ethanol (>25 mg/ml)
性状:Off-white solid
存储:-20°C
Activity (short version):Dual Plk/BRD4 inhibitor - Destabilizes Myc
Function / Pharmacology:BI 2536 was originally reported as a potent (IC50’s Plk1 = 0.83nM, Plk2 = 3.5nM and Plk3 = 9.0nM) and selective2 Polo-like kinase inhibitor (IC50’s Plk1 = 0.83nM, Plk2 = 3.5nM and Plk3 = 9.0nM) that caused mitotic arrest and apoptosis induction in various human cancer cell lines.1 It was later found to be a potent inhibitor (IC50 = 100nM) of BET family member BRD4 and able to potently suppress c-Myc expression in MM.1S multiple myeloma cells.3 BI 2536 destabilizes N-Myc by inhibiting the deactivation of the ubiquitin E3 ligase Fbw7 by Plk1.4
