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I-BET762
- 英文名称：I-BET762
- 品牌：WYTSCI
- 产地：进口
- 型号：1MG
- 货号：WT-AY-B11121
- cas：1260907-17-2
- 价格： ￥1/mg
- 发布日期： 2025-04-10
- 更新日期： 2025-05-23
产品详请
| 产地 | 进口 |
| 品牌 | WYTSCI |
| 货号 | WT-AY-B11121 |
| 用途 | 科研检测 |
| 英文名称 | I-BET762 |
| 包装规格 | 1MG |
| CAS编号 | 1260907-17-2 |
| 别名 | I-BET762 |
| 纯度 | 98+% |
| 分子式 | |
| 是否进口 | 是 |
纯度:98% by HPLC,;NMR (Conforms)
分子式:C22H22ClN5O2
分子量:423.90
溶剂:DMSO (>25 mg/ml) Ethanol (>25 mg/ml)
性状:Tan solid
存储:-20°C
Activity (short version):BET bromodomain inhibitor / Supresses Myc transcription
Function / Pharmacology:I-BET762 is a potent inhibitor of the BET family of bromodomains with no activity at bromodomains BAZ2B, SP140, ATAD2, CREBBO, and PCAF.1,2 IC50’s for H4Ac peptide displacement: BRD2 = 32.5nM, BRD3 = 42.4nM, BRD4 = 36.1nM.1 It was able to suppress proinflammatory proteins by macrophage, block acute inflammation in mice1, and suppressed the inflammatory function of T cells3. Inhibition of BET bromodomains results in downregulation of Myc transcription, an important oncogene.4
分子式:C22H22ClN5O2
分子量:423.90
溶剂:DMSO (>25 mg/ml) Ethanol (>25 mg/ml)
性状:Tan solid
存储:-20°C
Activity (short version):BET bromodomain inhibitor / Supresses Myc transcription
Function / Pharmacology:I-BET762 is a potent inhibitor of the BET family of bromodomains with no activity at bromodomains BAZ2B, SP140, ATAD2, CREBBO, and PCAF.1,2 IC50’s for H4Ac peptide displacement: BRD2 = 32.5nM, BRD3 = 42.4nM, BRD4 = 36.1nM.1 It was able to suppress proinflammatory proteins by macrophage, block acute inflammation in mice1, and suppressed the inflammatory function of T cells3. Inhibition of BET bromodomains results in downregulation of Myc transcription, an important oncogene.4
