纯度:98% by HPLC,;NMR (Conforms)
分子式:C18H22BrN5O3
分子量:436.30
溶剂:DMSO (>10 mg/ml)
性状:Off-white solid
存储:-20°C
Activity (short version):Chk1 inhibitor
Function / Pharmacology:LY2603618 is a potent (IC50 = 7nM) and selective (>1000x over Chk2) Checkpoint kinase 1 (Chk1) inhibitor.1 Chk1 is an important regulator of the DNA damage response – combination treatment of LY2603618 with other chemotherapeutic agents significantly increased tumor growth inhibition when compared to chemotherapeutic alone.2,3,4 LY2603618 caused a dramatic suppression of cell growth in MCF-7 and MDA-MB-231 human breast cancer cells via Chk1 inhibition induced upregulation of replication stress caused by oncogenes.5