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LY2603618
- 英文名称：LY2603618
- 品牌：WYTSCI
- 产地：进口
- 型号：1MG
- 货号：WT-AY-B11122
- cas：911222-45-2
- 价格： ￥1/mg
- 发布日期： 2025-04-10
- 更新日期： 2025-11-03
产品详请
| 产地 | 进口 |
| 品牌 | WYTSCI |
| 货号 | WT-AY-B11122 |
| 用途 | 科研检测 |
| 英文名称 | LY2603618 |
| 包装规格 | 1MG |
| CAS编号 | 911222-45-2 |
| 别名 | LY2603618 |
| 纯度 | 98+% |
| 分子式 | |
| 是否进口 | 是 |
纯度:98% by HPLC,;NMR (Conforms)
分子式:C18H22BrN5O3
分子量:436.30
溶剂:DMSO (>10 mg/ml)
性状:Off-white solid
存储:-20°C
Activity (short version):Chk1 inhibitor
Function / Pharmacology:LY2603618 is a potent (IC50 = 7nM) and selective (>1000x over Chk2) Checkpoint kinase 1 (Chk1) inhibitor.1 Chk1 is an important regulator of the DNA damage response – combination treatment of LY2603618 with other chemotherapeutic agents significantly increased tumor growth inhibition when compared to chemotherapeutic alone.2,3,4 LY2603618 caused a dramatic suppression of cell growth in MCF-7 and MDA-MB-231 human breast cancer cells via Chk1 inhibition induced upregulation of replication stress caused by oncogenes.5
分子式:C18H22BrN5O3
分子量:436.30
溶剂:DMSO (>10 mg/ml)
性状:Off-white solid
存储:-20°C
Activity (short version):Chk1 inhibitor
Function / Pharmacology:LY2603618 is a potent (IC50 = 7nM) and selective (>1000x over Chk2) Checkpoint kinase 1 (Chk1) inhibitor.1 Chk1 is an important regulator of the DNA damage response – combination treatment of LY2603618 with other chemotherapeutic agents significantly increased tumor growth inhibition when compared to chemotherapeutic alone.2,3,4 LY2603618 caused a dramatic suppression of cell growth in MCF-7 and MDA-MB-231 human breast cancer cells via Chk1 inhibition induced upregulation of replication stress caused by oncogenes.5
