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LY2603618
- 英文名称:LY2603618
- 品牌:WYTSCI
- 产地:进口
- 型号:1MG
- 货号:WT-AY-B11122
- cas:911222-45-2
- 价格: ¥1/mg
- 发布日期: 2025-04-10
- 更新日期: 2025-05-12
产品详请
产地 | 进口 |
品牌 | WYTSCI |
货号 | WT-AY-B11122 |
用途 | 科研检测 |
英文名称 | LY2603618 |
包装规格 | 1MG |
CAS编号 | 911222-45-2 |
别名 | LY2603618 |
纯度 | 98+% |
分子式 | |
是否进口 | 是 |
纯度:98% by HPLC,;NMR (Conforms)
分子式:C18H22BrN5O3
分子量:436.30
溶剂:DMSO (>10 mg/ml)
性状:Off-white solid
存储:-20°C
Activity (short version):Chk1 inhibitor
Function / Pharmacology:LY2603618 is a potent (IC50 = 7nM) and selective (>1000x over Chk2) Checkpoint kinase 1 (Chk1) inhibitor.1 Chk1 is an important regulator of the DNA damage response – combination treatment of LY2603618 with other chemotherapeutic agents significantly increased tumor growth inhibition when compared to chemotherapeutic alone.2,3,4 LY2603618 caused a dramatic suppression of cell growth in MCF-7 and MDA-MB-231 human breast cancer cells via Chk1 inhibition induced upregulation of replication stress caused by oncogenes.5
分子式:C18H22BrN5O3
分子量:436.30
溶剂:DMSO (>10 mg/ml)
性状:Off-white solid
存储:-20°C
Activity (short version):Chk1 inhibitor
Function / Pharmacology:LY2603618 is a potent (IC50 = 7nM) and selective (>1000x over Chk2) Checkpoint kinase 1 (Chk1) inhibitor.1 Chk1 is an important regulator of the DNA damage response – combination treatment of LY2603618 with other chemotherapeutic agents significantly increased tumor growth inhibition when compared to chemotherapeutic alone.2,3,4 LY2603618 caused a dramatic suppression of cell growth in MCF-7 and MDA-MB-231 human breast cancer cells via Chk1 inhibition induced upregulation of replication stress caused by oncogenes.5