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Alisertib
- 英文名称：Alisertib
- 品牌：WYTSCI
- 产地：进口
- 型号：1MG
- 货号：WT-AY-B11123
- cas：1028486-01-2
- 价格： ￥1/mg
- 发布日期： 2025-04-10
- 更新日期： 2025-12-08
产品详请
| 产地 | 进口 |
| 品牌 | WYTSCI |
| 货号 | WT-AY-B11123 |
| 用途 | 科研检测 |
| 英文名称 | Alisertib |
| 包装规格 | 1MG |
| CAS编号 | 1028486-01-2 |
| 别名 | Alisertib |
| 纯度 | 98+% |
| 分子式 | |
| 是否进口 | 是 |
纯度:98% by HPLC,;NMR (Conforms)
分子式:C27H20ClFN4O4
分子量:518.92
溶剂:DMSO (5 mg/ml)
性状:Off-white solid
存储:-20°C
Activity (short version):Aurora A inhibitor; Destablizes Myc
Function / Pharmacology:Alisertib (MLN8237) is a highly selective and potent (IC50 = 1 nM) cell permeable inhibitor of Aurora A with off-target binding at GABAA (IC50 = 490 nM).1 It disrupts the Aurora A-Myc complex leading to Myc degradation2 in Myc amplified neuroblastomas3 and p53-mutant human hepatocellular carcinoma cell4. Alisertib has been found to induce apoptosis and autophagy in breast cancer5 and melanoma6 cells via suppression of activation of the p38 MAPK pathway.
分子式:C27H20ClFN4O4
分子量:518.92
溶剂:DMSO (5 mg/ml)
性状:Off-white solid
存储:-20°C
Activity (short version):Aurora A inhibitor; Destablizes Myc
Function / Pharmacology:Alisertib (MLN8237) is a highly selective and potent (IC50 = 1 nM) cell permeable inhibitor of Aurora A with off-target binding at GABAA (IC50 = 490 nM).1 It disrupts the Aurora A-Myc complex leading to Myc degradation2 in Myc amplified neuroblastomas3 and p53-mutant human hepatocellular carcinoma cell4. Alisertib has been found to induce apoptosis and autophagy in breast cancer5 and melanoma6 cells via suppression of activation of the p38 MAPK pathway.
