纯度:98% by HPLC,;NMR (Conforms)
分子式:C12H7F2NO3S2
分子量:315.32
溶剂:DMSO (25 mg/ml)
性状:Off-white solid
存储:-20°C
Activity (short version):USP7 inhibitor
Function / Pharmacology:P22077 is a selective (tested against 23 other DUBs) inhibitor of USP7 (IC50 = 8 μM) and the closely related USP47.1,2 It destabilizes claspin, a scaffolding protein involved in regulating Chk1 kinase, a DNA damage response enzyme.2 P22077 inhibits neuroblastoma growth via induction of p53-mediated apoptosis.3 N-Myc was destabilized by P22077 inhibition of USP7 in human neuroblastoma cells.4 It was able to stabilize p53 levels in conjunction with an Mdm2 inhibitor (Nutlin-3, Cat# 10-1350) in HCT116 colorectal carcinoma cells.5