纯度:98% by TLC;NMR (Conforms)
分子式:C19H12Cl2N4O3
分子量:415.23
溶剂:DMSO (>25 mg/ml)
性状:Off-white to pale pink solid
存储:-20°C
Activity (short version):cGAS inhibitor
Function / Pharmacology:Inhibitor of cyclic GMP-AMP synthase (cGAS), an important innate immune system sensor of foreign cytoplasmic double-stranded DNA.1,2 IC50 = 0.70 μM in dsDNA-stimulated RAW macrophages1 and ~0.80 μM in wild type human THP-1 cells2. It is selective for cGAS with no targeting of IFNB1 protein, interferon receptors, or downstream signaling components of the JAK/STAT pathway. RU.521 was able to significantly increase cardiac output in a mouse model of sepsis.3 Active in both mouse and human cell lines.