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S07-2010
- 英文名称：S07-2010
- 品牌：WYTSCI
- 产地：进口
- 型号：1MG
- 货号：WT-AY-B11134
- cas：1223194-71-5
- 价格： ￥1/mg
- 发布日期： 2025-04-10
- 更新日期： 2025-05-23
产品详请
| 产地 | 进口 |
| 品牌 | WYTSCI |
| 货号 | WT-AY-B11134 |
| 用途 | 科研检测 |
| 英文名称 | S07-2010 |
| 包装规格 | 1MG |
| CAS编号 | 1223194-71-5 |
| 别名 | S07-2010 |
| 纯度 | 98+% |
| 分子式 | |
| 是否进口 | 是 |
纯度:98% by TLC;NMR (Conforms)
分子式:C19H21N3O3S
分子量:371.46
溶剂:DMSO (50 mg/ml)
性状:Off-white solid
存储:-20°C
Activity (short version):pan-AKR1C inhibitor
Function / Pharmacology:S07-2010 is a pan-aldo-keto reductase 1C (AKR1C) inhibitor (IC50’s for AKR1C isoforms: 1C1 = 470 nM, 1C2 = 730 nM, 1C3 = 190 nM, 1C4 = 360 nM). Dysregulated AKR1C3 expression (and overexpression of all AKR1C isoforms in general) is related to resistance to radio- and chemotherapy in various tumor types and is associated with development of and poor prognosis in many cancers. S07-2010 displayed cytotoxicity to doxorubicin-resistant MCF-7 cells (IC50 = 127.5 μM) and cisplatin-resistant A549 cells (IC50 = 5.51 μM). Combination treatment of chemotherapeutic agents and S07-2010 showed synergistic effects in drug-resistant cell lines.
分子式:C19H21N3O3S
分子量:371.46
溶剂:DMSO (50 mg/ml)
性状:Off-white solid
存储:-20°C
Activity (short version):pan-AKR1C inhibitor
Function / Pharmacology:S07-2010 is a pan-aldo-keto reductase 1C (AKR1C) inhibitor (IC50’s for AKR1C isoforms: 1C1 = 470 nM, 1C2 = 730 nM, 1C3 = 190 nM, 1C4 = 360 nM). Dysregulated AKR1C3 expression (and overexpression of all AKR1C isoforms in general) is related to resistance to radio- and chemotherapy in various tumor types and is associated with development of and poor prognosis in many cancers. S07-2010 displayed cytotoxicity to doxorubicin-resistant MCF-7 cells (IC50 = 127.5 μM) and cisplatin-resistant A549 cells (IC50 = 5.51 μM). Combination treatment of chemotherapeutic agents and S07-2010 showed synergistic effects in drug-resistant cell lines.
