纯度:98% by HPLC;NMR (Conforms)
分子式:C29H44N8O3
分子量:552.72
溶剂:DMSO (25 mg/ml)
性状:Off-white to pale pink solid
存储:-20°C
Activity (short version):FLT3 inhibitor
Function / Pharmacology:Potent inhibitor of FLT3 (IC50 = 5 nM, wild-type FLT3) with more potent activity against all FLT3 mutants.1 It also potently inhibits Axl (IC50 = 41 nM). Clinically useful in the treatment of acute myeloid leukemia. Gilteritinib has also been shown to inhibit glutamine uptake and utilization via downregulation of glutamine transporters.2