纯度:>98% by HPLC;NMR (Conforms)
分子式:C31H29Cl2F2N3O4
分子量:616.49
溶剂:DMSO (>25 mg/ml)
性状:White solid
存储:-20°C
Activity (short version):p53-MDM2 inhibitor
Function / Pharmacology:Idasanutlin is a potent (IC50 = 6 nM) and selective inhibitor of MDM2, the primary negative regulator of p53.1 It blocks the p53-MDM2 interaction activating the p53 pathway leading to cell cycle arrest and apoptosis. Idasanutlin has displayed efficacy in the treatment of multiple cancers alone and in combination with other chemotherapeutics.2-6