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PRIMA-1MET
- 英文名称:PRIMA-1MET
- 品牌:WYTSCI
- 产地:进口
- 型号:1MG
- 货号:WT-AY-B11142
- cas:5291-32-7
- 价格: ¥1/mg
- 发布日期: 2025-04-10
- 更新日期: 2025-05-23
产品详请
产地 | 进口 |
品牌 | WYTSCI |
货号 | WT-AY-B11142 |
用途 | 科研检测 |
英文名称 | PRIMA-1MET |
包装规格 | 1MG |
CAS编号 | 5291-32-7 |
别名 | PRIMA-1MET |
纯度 | 98+% |
分子式 | |
是否进口 | 是 |
纯度:95%,;NMR (Conforms)
分子式:C10H17NO3
分子量:199.25
溶剂:DMSO (20 mg/ml)
性状:White solid
存储:-20°C
Activity (short version):Reactivates mutant p53
Function / Pharmacology:PRIMA-1MET reactivates mutant p53, an important tumor suppressor gene, in cancer cells.1 It induces p53-dependent mitochondrial apoptosis via activation of caspase-2.2 PRIMA-1MET showed significant antitumor activity in multiple myeloma via activation of p733 and had previously been shown to target p53 family members p63 and p734. Tumor cell death by PRIMA-1MET has been also shown to be caused by glutathione depletion and induced ROS production in a p53 independent manner.5-7 PRIMA-1MET probably induces tumor cell death by both reactivating mutant p53 and inhibiting cellular thiol-dependent redox systems.8
分子式:C10H17NO3
分子量:199.25
溶剂:DMSO (20 mg/ml)
性状:White solid
存储:-20°C
Activity (short version):Reactivates mutant p53
Function / Pharmacology:PRIMA-1MET reactivates mutant p53, an important tumor suppressor gene, in cancer cells.1 It induces p53-dependent mitochondrial apoptosis via activation of caspase-2.2 PRIMA-1MET showed significant antitumor activity in multiple myeloma via activation of p733 and had previously been shown to target p53 family members p63 and p734. Tumor cell death by PRIMA-1MET has been also shown to be caused by glutathione depletion and induced ROS production in a p53 independent manner.5-7 PRIMA-1MET probably induces tumor cell death by both reactivating mutant p53 and inhibiting cellular thiol-dependent redox systems.8