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PK11007
  • 英文名称:PK11007
  • 品牌:WYTSCI
  • 产地:进口
  • 型号:1MG
  • 货号:WT-AY-B11143
  • cas:874146-69-7
  • 价格: ¥1/mg
  • 发布日期: 2025-04-10
  • 更新日期: 2025-05-23
产品详请
产地 进口
品牌 WYTSCI
货号 WT-AY-B11143
用途 科研检测
英文名称 PK11007
包装规格 1MG
CAS编号 874146-69-7
别名 PK11007
纯度 98+%
分子式
是否进口
纯度:>98% by HPLC;NMR (Conforms)
分子式:C15H11ClFN5O3S2
分子量:427.85
溶剂:DMSO (>25 mg/ml)
性状:White solid
存储:-20°C
Activity (short version):Reactivator of mutant p53
Function / Pharmacology:PK11007 reactivates mutant p53 via selective alkylation of two cysteine residues without compromising DNA-binding ability.1 p53 target genes p21 and PUMA were activated by treatment with PK11007. Mutant p53-containing cancer cells were more sensitive to PK11007 than wild-type with mutant cells showing greatly reduced viability. It also generated high levels of reactive oxygen species and induced ER stress in a p53-independent (and dependent on glutathione depletion) manner that resulted in cell death. PK11007 inhibited cellular proliferation, induced apoptosis, and blocked cell migration in a panel of 17 breast cancer lines including triple-negative breast cancer (IC50s: 2.3 to 42.2 μM).2
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