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PK11007
- 英文名称:PK11007
- 品牌:WYTSCI
- 产地:进口
- 型号:1MG
- 货号:WT-AY-B11143
- cas:874146-69-7
- 价格: ¥1/mg
- 发布日期: 2025-04-10
- 更新日期: 2025-05-23
产品详请
产地 | 进口 |
品牌 | WYTSCI |
货号 | WT-AY-B11143 |
用途 | 科研检测 |
英文名称 | PK11007 |
包装规格 | 1MG |
CAS编号 | 874146-69-7 |
别名 | PK11007 |
纯度 | 98+% |
分子式 | |
是否进口 | 是 |
纯度:>98% by HPLC;NMR (Conforms)
分子式:C15H11ClFN5O3S2
分子量:427.85
溶剂:DMSO (>25 mg/ml)
性状:White solid
存储:-20°C
Activity (short version):Reactivator of mutant p53
Function / Pharmacology:PK11007 reactivates mutant p53 via selective alkylation of two cysteine residues without compromising DNA-binding ability.1 p53 target genes p21 and PUMA were activated by treatment with PK11007. Mutant p53-containing cancer cells were more sensitive to PK11007 than wild-type with mutant cells showing greatly reduced viability. It also generated high levels of reactive oxygen species and induced ER stress in a p53-independent (and dependent on glutathione depletion) manner that resulted in cell death. PK11007 inhibited cellular proliferation, induced apoptosis, and blocked cell migration in a panel of 17 breast cancer lines including triple-negative breast cancer (IC50s: 2.3 to 42.2 μM).2
分子式:C15H11ClFN5O3S2
分子量:427.85
溶剂:DMSO (>25 mg/ml)
性状:White solid
存储:-20°C
Activity (short version):Reactivator of mutant p53
Function / Pharmacology:PK11007 reactivates mutant p53 via selective alkylation of two cysteine residues without compromising DNA-binding ability.1 p53 target genes p21 and PUMA were activated by treatment with PK11007. Mutant p53-containing cancer cells were more sensitive to PK11007 than wild-type with mutant cells showing greatly reduced viability. It also generated high levels of reactive oxygen species and induced ER stress in a p53-independent (and dependent on glutathione depletion) manner that resulted in cell death. PK11007 inhibited cellular proliferation, induced apoptosis, and blocked cell migration in a panel of 17 breast cancer lines including triple-negative breast cancer (IC50s: 2.3 to 42.2 μM).2