纯度:97% by HPLC;NMR (Conforms)
分子式:C23H29ClN4O2S
分子量:461.02
溶剂:DMSO (>25 mg/ml)
性状:Tan solid
存储:-20°C
Activity (short version):WIP1 phosphatase inhibitor
Function / Pharmacology:Potent allosteric inhibitor of WIP1 phosphatase (IC50 = 6 nM), a negative regulator of the DNA damage response.1 It displayed no inhibition of 21 other phosphatases. Active in xenograft model DoHH2 B-cell lymphoma. GSK2830371 in combination with MDM2 inhibitors has been shown to be efficacious in the treatment of various cancers including liver adenocarcinoma2, acute myeloid leukemia3, and breast4. It enhances phosphorylation of the tumor suppressor p53 leading to activation.5,6