纯度:98% by HPLC;NMR (Conforms)
分子式:C20H23N3O2·HCl
分子量:373.88
溶剂:DMSO (>25 mg/ml)
性状:Off-white solid
存储:-20°C
Activity (short version):Sigma-1 antagonist
Function / Pharmacology:S1RA (E-52862) is a potent and selective ?1 antagonist with weak binding at ?2 (IC50’s: ?1 = 17nM, ?2 = 9300nM).1,2 S1RA abolished mechanical and thermal hyperalgesia in mice with carrageenan-induced acute inflammation by enhancing the action of endogenous opioid peptides of immune origin in a ?1 dependent manner.3 BD1063 potentiated μ-opioid antinociception in mice in a ?-dependent manner.4 S1RA displayed neuroprotective effects in a mouse model of ischemic stroke.5