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S1RA
- 英文名称:S1RA
- 品牌:WYTSCI
- 产地:进口
- 型号:1MG
- 货号:WT-AY-B11150
- cas:1265917-14-3
- 价格: ¥1/mg
- 发布日期: 2025-04-10
- 更新日期: 2025-05-12
产品详请
产地 | 进口 |
品牌 | WYTSCI |
货号 | WT-AY-B11150 |
用途 | 科研检测 |
英文名称 | S1RA |
包装规格 | 1MG |
CAS编号 | 1265917-14-3 |
别名 | S1RA |
纯度 | 98+% |
分子式 | |
是否进口 | 是 |
纯度:98% by HPLC;NMR (Conforms)
分子式:C20H23N3O2·HCl
分子量:373.88
溶剂:DMSO (>25 mg/ml)
性状:Off-white solid
存储:-20°C
Activity (short version):Sigma-1 antagonist
Function / Pharmacology:S1RA (E-52862) is a potent and selective ?1 antagonist with weak binding at ?2 (IC50’s: ?1 = 17nM, ?2 = 9300nM).1,2 S1RA abolished mechanical and thermal hyperalgesia in mice with carrageenan-induced acute inflammation by enhancing the action of endogenous opioid peptides of immune origin in a ?1 dependent manner.3 BD1063 potentiated μ-opioid antinociception in mice in a ?-dependent manner.4 S1RA displayed neuroprotective effects in a mouse model of ischemic stroke.5
分子式:C20H23N3O2·HCl
分子量:373.88
溶剂:DMSO (>25 mg/ml)
性状:Off-white solid
存储:-20°C
Activity (short version):Sigma-1 antagonist
Function / Pharmacology:S1RA (E-52862) is a potent and selective ?1 antagonist with weak binding at ?2 (IC50’s: ?1 = 17nM, ?2 = 9300nM).1,2 S1RA abolished mechanical and thermal hyperalgesia in mice with carrageenan-induced acute inflammation by enhancing the action of endogenous opioid peptides of immune origin in a ?1 dependent manner.3 BD1063 potentiated μ-opioid antinociception in mice in a ?-dependent manner.4 S1RA displayed neuroprotective effects in a mouse model of ischemic stroke.5