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Siramesine
- 英文名称：Siramesine
- 品牌：WYTSCI
- 产地：进口
- 型号：1MG
- 货号：WT-AY-B11151
- cas：147817-50-3
- 价格： ￥1/mg
- 发布日期： 2025-04-10
- 更新日期： 2025-05-23
产品详请
| 产地 | 进口 |
| 品牌 | WYTSCI |
| 货号 | WT-AY-B11151 |
| 用途 | 科研检测 |
| 英文名称 | Siramesine |
| 包装规格 | 1MG |
| CAS编号 | 147817-50-3 |
| 别名 | Siramesine |
| 纯度 | 98+% |
| 分子式 | |
| 是否进口 | 是 |
纯度:98% by HPLC;NMR (Conforms)
分子式:C30H31FN2O
分子量:454.59
溶剂:DMSO (>25 mg/ml)
性状:White solid
存储:-20°C
Activity (short version):Sigma-2 agonist
Function / Pharmacology:Siramesine (Lu 28-179) is a ?2 selective agonist (IC50’s: ?1 = 17nM, ?2 = 0.2nM).1 It produced non-sedating potent and long-last anxiolytic effects in rodents.2 Siramesine induced caspase-independent programmed cell death in various cancer cell lines via increased levels of ROS and lysosomal leakage.3,4,5 Mitochondrial destabilization via loss of membrane potential and increased ROS has also been offered as a mechanism of action for the triggering of cell death by Siramesine.6
分子式:C30H31FN2O
分子量:454.59
溶剂:DMSO (>25 mg/ml)
性状:White solid
存储:-20°C
Activity (short version):Sigma-2 agonist
Function / Pharmacology:Siramesine (Lu 28-179) is a ?2 selective agonist (IC50’s: ?1 = 17nM, ?2 = 0.2nM).1 It produced non-sedating potent and long-last anxiolytic effects in rodents.2 Siramesine induced caspase-independent programmed cell death in various cancer cell lines via increased levels of ROS and lysosomal leakage.3,4,5 Mitochondrial destabilization via loss of membrane potential and increased ROS has also been offered as a mechanism of action for the triggering of cell death by Siramesine.6
