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Elesclomol
  • 英文名称:Elesclomol
  • 品牌:WYTSCI
  • 产地:进口
  • 型号:1MG
  • 货号:WT-AY-B11160
  • cas:488832-69-5
  • 价格: ¥1/mg
  • 发布日期: 2025-04-10
  • 更新日期: 2025-05-23
产品详请
产地 进口
品牌 WYTSCI
货号 WT-AY-B11160
用途 科研检测
英文名称 Elesclomol
包装规格 1MG
CAS编号 488832-69-5
别名 Elesclomol
纯度 98+%
分子式
是否进口
纯度:98% by HPLC;NMR (Conforms)
分子式:C19H20N4O2S2
分子量:400.52
溶剂:DMSO (50 mg/ml)
性状:Pale yellow solid
存储:-20°C
Activity (short version):Copper chelator/Cuproptosis inducer
Function / Pharmacology:Elesclomol induced oxidative stress in cancer cells via rapid generation of reactive oxygen species.1 It preferentially binds copper ions outside the cell and selectively transports inside the mitochondria with subsequent reactive oxygen species generation leading to apoptosis.2,3 Elesclomol can restore copper homeostasis in models of copper deficiency and disorders of copper metabolism.4,5 Copper-induced cell death (Cuproptosis) caused by Elesclomol is now believed to occur via direct binding of copper to lipoylated components of the tricarboxylic acid cycle causing protein aggregation and subsequent iron-sulfur protein loss leading to proteotoxic stress and cell death.6
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