纯度:98% by HPLC;NMR (Conforms)
分子式:C34H38N2O4
分子量:538.69
溶剂:DMSO (>70 mg/ml) Ethanol (>30 mg/ml)
性状:Off-white solid
存储:-20°C
Activity (short version):Glutamine transport inhibitor
Function / Pharmacology:Selective inhibitor of the alanine-serine-cysteine transporter 2 (ASCT2 or SLC1A5; IC50 = 9.0 μM rat and 9.6 μM human).1,2 It inhibited the uptake of both glutamine and possibly other amino acids in human cancer cells and reduced in vitro viability by at least 20% in more than half of 29 cancer cell lines screened.2 V-9302 decreased mTOR activity, elevated autophagy, and increased oxidative stress in multiple animal cancer models.2-5