纯度:98% by HPLC, NMR (Confirms)
分子式:C23H30ClN3O·2HCl
分子量:472.88
溶剂:Water (>25 mg/ml) DMSO (>10 10 mg/ml)
性状:Yellow solid
存储:-20°C
Activity (short version):Antiprotozoan / Anticancer
Function / Pharmacology:Quinacrine is an antiprotozoan drug used for malaria and giardiasis and has recently been investigated in treating lupus, as an anticancer agent, inflammation, and as a female sterilization agent.1 It has been found to have synergistic effects with vorinostat in the treatment of T-cell acute lymphoblastic leukemia via mitophagy blockage and an increase in ROS.2 Quinacrine displayed antitumor effects an intestinal cancer mouse model and HCT116 p53-/- xenografts via reduction in Chk1/2 expression and cell death induction in the G2-M phase.3 It promotes autophagic cell death in ovarian cancer cells via downregulation of p62/SQSTM1.4 Quinacrine is also an inhibitor of phospholipase A2.5