|
GFB-8438
- 英文名称：GFB-8438
- 品牌：WYTSCI
- 产地：进口
- 型号：1MG
- 货号：WT-AY-B11168
- cas：2304549-73-1
- 价格： ￥1/mg
- 发布日期： 2025-04-10
- 更新日期： 2025-05-12
产品详请
| 产地 | 进口 |
| 品牌 | WYTSCI |
| 货号 | WT-AY-B11168 |
| 用途 | 科研检测 |
| 英文名称 | GFB-8438 |
| 包装规格 | 1MG |
| CAS编号 | 2304549-73-1 |
| 别名 | GFB-8438 |
| 纯度 | 98+% |
| 分子式 | |
| 是否进口 | 是 |
纯度:>98% by HPLC;NMR (Conforms)
分子式:C16H14ClF3N4O2
分子量:386.76
溶剂:DMSO (>25 mg/ml)
性状:Off-white solid
存储:-20°C
Activity (short version):Selective TRPC5 inhibitor
Function / Pharmacology:GFB-8438 is a potent (IC50 = 180 nM Qpatch and 280 nM whole cells) and selective inhibitor of TRPC4 and 5.1 It displayed excellent selectivity against other TRP family members as well as NaV1.5, 50 kinases and 87 other receptor targets along with good pharmacokinetic properties. GFB-8438 protected mouse podocytes from injury induced by protamine sulfate and demonstrated efficacy in a hypertensive DOCA-salt rat model suggesting potential therapeutic use for the treatment of chronic kidney disease.
分子式:C16H14ClF3N4O2
分子量:386.76
溶剂:DMSO (>25 mg/ml)
性状:Off-white solid
存储:-20°C
Activity (short version):Selective TRPC5 inhibitor
Function / Pharmacology:GFB-8438 is a potent (IC50 = 180 nM Qpatch and 280 nM whole cells) and selective inhibitor of TRPC4 and 5.1 It displayed excellent selectivity against other TRP family members as well as NaV1.5, 50 kinases and 87 other receptor targets along with good pharmacokinetic properties. GFB-8438 protected mouse podocytes from injury induced by protamine sulfate and demonstrated efficacy in a hypertensive DOCA-salt rat model suggesting potential therapeutic use for the treatment of chronic kidney disease.
