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NGI-1
  • 英文名称:NGI-1
  • 品牌:WYTSCI
  • 产地:进口
  • 型号:1MG
  • 货号:WT-AY-B11173
  • cas:790702-57-7
  • 价格: ¥1/mg
  • 发布日期: 2025-04-10
  • 更新日期: 2025-05-23
产品详请
产地 进口
品牌 WYTSCI
货号 WT-AY-B11173
用途 科研检测
英文名称 NGI-1
包装规格 1MG
CAS编号 790702-57-7
别名 NGI-1
纯度 98+%
分子式
是否进口
纯度:98% by TLC NMR (Confirms)
分子式:C17H22N4O3S2
分子量:394.51
溶剂:DMSO (5 mg/ml)
性状:White solid
存储:-20°C
Activity (short version):Oligosaccharyltransferase (OST) inhibitor
Function / Pharmacology:NGI-1 is a cell-permeable inhibitor of oligosaccharyltransferase (OST) – IC50 = 1.1 μM.1 It blocks cell-surface localization and signaling of the epidermal growth factor receptor (EGFR) glycoprotein and selectively arrests proliferation only in cells dependent on EGFR for survival. NGI-1 caused G1 arrest and senescence in RTK-dependent NSCLC cells (PC9, HCC827, H3255,H1581). NGI-1 displays antiviral behavior against various flaviviruses (Dengue, West Nile, Yellow fever and Zika).2 It also was able to overcome resistance to EGFR tyrosine kinase inhibitors in mutant NSCLC cells3 and enhance radiosensitivity and cytotoxic effects of chemotherapy in glioma cells with high levels of RTK activation4.
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