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(+/-) RK-682
  • 英文名称:(+/-) RK-682
  • 品牌:WYTSCI
  • 产地:进口
  • 型号:1MG
  • 货号:WT-AY-B11175
  • cas:154639-24-4
  • 价格: ¥1/mg
  • 发布日期: 2025-04-10
  • 更新日期: 2025-05-23
产品详请
产地 进口
品牌 WYTSCI
货号 WT-AY-B11175
用途 科研检测
英文名称 (+/-) RK-682
包装规格 1MG
CAS编号 154639-24-4
别名 (+/-) RK-682
纯度 98+%
分子式
是否进口
纯度:98% by TLC,;NMR (Conforms)
分子式:C21H36O5
分子量:368.52
溶剂:DMSO (25 mg/ml) Ethanol (10 mg/ml)
性状:Off-white or Yellow solid
存储:-20°C
Activity (short version):Tyrosine phopshatase inhibitor
Function / Pharmacology:RK-682 is a protein tyrosine phosphatase inhibitor (IC50’s = 54 μM for CD45, 2.0 μM for VHR; did not inhibit cdc25B) originally isolated from the fermentation of Streptomyces sp. 88-682.1 Inhibits cell cycle at G1/S. RK-682 has also been shown to inhibit PLA2 (IC50 = 16 μM)2, HIV-1 protease (IC50 = 84 μM)3, and heparanase (IC50 = 17 μM)4. Natural RK-682 (R-isomer) and synthetic racemic material have identical phosphatase activity.5 Care should be taken when using RK-682 in the presence of metal salts – RK-682 readily forms metal complexes that affects its phosphatase inhibitory activity.6 RK-682 has been identified as a potential promiscuous inhibitor.7
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