纯度:98% by TLC,;NMR (Conforms)
分子式:C21H36O5
分子量:368.52
溶剂:DMSO (25 mg/ml) Ethanol (10 mg/ml)
性状:Off-white or Yellow solid
存储:-20°C
Activity (short version):Tyrosine phopshatase inhibitor
Function / Pharmacology:RK-682 is a protein tyrosine phosphatase inhibitor (IC50’s = 54 μM for CD45, 2.0 μM for VHR; did not inhibit cdc25B) originally isolated from the fermentation of Streptomyces sp. 88-682.1 Inhibits cell cycle at G1/S. RK-682 has also been shown to inhibit PLA2 (IC50 = 16 μM)2, HIV-1 protease (IC50 = 84 μM)3, and heparanase (IC50 = 17 μM)4. Natural RK-682 (R-isomer) and synthetic racemic material have identical phosphatase activity.5 Care should be taken when using RK-682 in the presence of metal salts – RK-682 readily forms metal complexes that affects its phosphatase inhibitory activity.6 RK-682 has been identified as a potential promiscuous inhibitor.7