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(+/-) RK-682
- 英文名称:(+/-) RK-682
- 品牌:WYTSCI
- 产地:进口
- 型号:1MG
- 货号:WT-AY-B11175
- cas:154639-24-4
- 价格: ¥1/mg
- 发布日期: 2025-04-10
- 更新日期: 2025-05-23
产品详请
产地 | 进口 |
品牌 | WYTSCI |
货号 | WT-AY-B11175 |
用途 | 科研检测 |
英文名称 | (+/-) RK-682 |
包装规格 | 1MG |
CAS编号 | 154639-24-4 |
别名 | (+/-) RK-682 |
纯度 | 98+% |
分子式 | |
是否进口 | 是 |
纯度:98% by TLC,;NMR (Conforms)
分子式:C21H36O5
分子量:368.52
溶剂:DMSO (25 mg/ml) Ethanol (10 mg/ml)
性状:Off-white or Yellow solid
存储:-20°C
Activity (short version):Tyrosine phopshatase inhibitor
Function / Pharmacology:RK-682 is a protein tyrosine phosphatase inhibitor (IC50’s = 54 μM for CD45, 2.0 μM for VHR; did not inhibit cdc25B) originally isolated from the fermentation of Streptomyces sp. 88-682.1 Inhibits cell cycle at G1/S. RK-682 has also been shown to inhibit PLA2 (IC50 = 16 μM)2, HIV-1 protease (IC50 = 84 μM)3, and heparanase (IC50 = 17 μM)4. Natural RK-682 (R-isomer) and synthetic racemic material have identical phosphatase activity.5 Care should be taken when using RK-682 in the presence of metal salts – RK-682 readily forms metal complexes that affects its phosphatase inhibitory activity.6 RK-682 has been identified as a potential promiscuous inhibitor.7
分子式:C21H36O5
分子量:368.52
溶剂:DMSO (25 mg/ml) Ethanol (10 mg/ml)
性状:Off-white or Yellow solid
存储:-20°C
Activity (short version):Tyrosine phopshatase inhibitor
Function / Pharmacology:RK-682 is a protein tyrosine phosphatase inhibitor (IC50’s = 54 μM for CD45, 2.0 μM for VHR; did not inhibit cdc25B) originally isolated from the fermentation of Streptomyces sp. 88-682.1 Inhibits cell cycle at G1/S. RK-682 has also been shown to inhibit PLA2 (IC50 = 16 μM)2, HIV-1 protease (IC50 = 84 μM)3, and heparanase (IC50 = 17 μM)4. Natural RK-682 (R-isomer) and synthetic racemic material have identical phosphatase activity.5 Care should be taken when using RK-682 in the presence of metal salts – RK-682 readily forms metal complexes that affects its phosphatase inhibitory activity.6 RK-682 has been identified as a potential promiscuous inhibitor.7