|
BI 749327
- 英文名称：BI 749327
- 品牌：WYTSCI
- 产地：进口
- 型号：1MG
- 货号：WT-AY-B11179
- cas：2361241-23-6
- 价格： ￥1/mg
- 发布日期： 2025-04-10
- 更新日期： 2025-05-23
产品详请
| 产地 | 进口 |
| 品牌 | WYTSCI |
| 货号 | WT-AY-B11179 |
| 用途 | 科研检测 |
| 英文名称 | BI 749327 |
| 包装规格 | 1MG |
| CAS编号 | 2361241-23-6 |
| 别名 | BI 749327 |
| 纯度 | 98+% |
| 分子式 | |
| 是否进口 | 是 |
纯度:98% by HPLC;NMR (Conforms)
分子式:C23H21F3N4O2
分子量:442.44
溶剂:DMSO (25 mg/ml)
性状:White solid
存储:-20°C
Activity (short version):Selective TRPC6 antagonist
Function / Pharmacology:Potent (IC50 = 13 nM mouse TRPC6, 19 nM human TRPC6) and selective (85-fold over TRPC3, 42-fold over TRC7) orally available blocker of TRPC6.1 It suppressed interstitial fibrosis and associated molecular signaling in mouse heart and kidney disease models. BI 749327 reversed established pulmonary hypertension by 50% via regression of pulmonary remodeling in a mouse model.2
分子式:C23H21F3N4O2
分子量:442.44
溶剂:DMSO (25 mg/ml)
性状:White solid
存储:-20°C
Activity (short version):Selective TRPC6 antagonist
Function / Pharmacology:Potent (IC50 = 13 nM mouse TRPC6, 19 nM human TRPC6) and selective (85-fold over TRPC3, 42-fold over TRC7) orally available blocker of TRPC6.1 It suppressed interstitial fibrosis and associated molecular signaling in mouse heart and kidney disease models. BI 749327 reversed established pulmonary hypertension by 50% via regression of pulmonary remodeling in a mouse model.2
