纯度:>98% by HPLC,;NMR (Conforms)
分子式:C20H23N3O3
分子量:353.42
溶剂:DMSO (5 mg/ml)
性状:White solid
存储:-20°C
Activity (short version):BRD9 bromodomain inhibitor
Function / Pharmacology:Potent, selective, and cell permeable inhibitor of the BRD9 bromodomain, a subunit of the switch/sucrose nonfermentable (SWI/SNF) chromatin remodeling complex (IC50 = 75 nM).1 It displayed antitumor activity in an acute myeloid leukemia xenograft model. BI-9564 displayed cytotoxic and anti-proliferative effects in 5 rhabdoid tumor cell lines.2