纯度:99% by HPLC,;NMR (Conforms)
分子式:C18H21F3N6O2
分子量:410.39
溶剂:DMSO (15 mg/ml)
性状:White solid
存储:-20°C
Activity (short version):PI3-kinase inhibitor
Function / Pharmacology:Potent pan-Class I PI3-kinase inhibitor (IC50’s: p110α = 52 nM, p110? = 166 nM, p110δ = 116 nM. P110g = 262 nM).1,2 It inhibited microtubule dynamics at in vitro concentrations >1μM and doses above 50mg/kg in mice.3 Buparlisib lead to a precipitous drop in DNA synthesis in a mouse model of BRCA1-linked triple-negative breast cancer with less affect in normal tissue.4