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HD2
- 英文名称：HD2
- 品牌：WYTSCI
- 产地：进口
- 型号：1MG
- 货号：WT-AY-B11185
- cas：2543578-57-8
- 价格： ￥1/mg
- 发布日期： 2025-04-10
- 更新日期： 2025-05-12
产品详请
| 产地 | 进口 |
| 品牌 | WYTSCI |
| 货号 | WT-AY-B11185 |
| 用途 | 科研检测 |
| 英文名称 | HD2 |
| 包装规格 | 1MG |
| CAS编号 | 2543578-57-8 |
| 别名 | HD2 |
| 纯度 | 98+% |
| 分子式 | |
| 是否进口 | 是 |
纯度:>98% by HPLC;NMR (Conforms)
分子式:C18H14ClF3N4OS
分子量:426.84
溶剂:DMSO (>60 mg/ml)
性状:White solid
存储:-20°C
Activity (short version):DCN1 inhibitor
Function / Pharmacology:HD2 is a potent (IC50 = 2.96 nM) inhibitor of DCN1, an important co-E3 ligase of neddylation. Displays favorable pharmacokinetics and low toxicity (including no hepatotoxicity). Selective against other DCN family members as well as ACE. HD2 reduced the migration and proliferation of Ang II-treated cardiac fibroblasts. Active in an isoproterenol-induced pathological cardiac remodeling and fibrosis mouse model. HD2 is a promising new therapeutic option for treatment of cardiac remodeling and fibrosis.
分子式:C18H14ClF3N4OS
分子量:426.84
溶剂:DMSO (>60 mg/ml)
性状:White solid
存储:-20°C
Activity (short version):DCN1 inhibitor
Function / Pharmacology:HD2 is a potent (IC50 = 2.96 nM) inhibitor of DCN1, an important co-E3 ligase of neddylation. Displays favorable pharmacokinetics and low toxicity (including no hepatotoxicity). Selective against other DCN family members as well as ACE. HD2 reduced the migration and proliferation of Ang II-treated cardiac fibroblasts. Active in an isoproterenol-induced pathological cardiac remodeling and fibrosis mouse model. HD2 is a promising new therapeutic option for treatment of cardiac remodeling and fibrosis.
