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SPHINX31
- 英文名称:SPHINX31
- 品牌:WYTSCI
- 产地:进口
- 型号:1MG
- 货号:WT-AY-B11188
- cas:1818389-84-2
- 价格: ¥1/mg
- 发布日期: 2025-04-10
- 更新日期: 2025-05-12
产品详请
产地 | 进口 |
品牌 | WYTSCI |
货号 | WT-AY-B11188 |
用途 | 科研检测 |
英文名称 | SPHINX31 |
包装规格 | 1MG |
CAS编号 | 1818389-84-2 |
别名 | SPHINX31 |
纯度 | 98+% |
分子式 | |
是否进口 | 是 |
纯度:>98% by HPLC;NMR (Conforms)
分子式:C27H24F3N5O2
分子量:507.52
溶剂:DMSO (15 mg/ml with warming)
性状:Off-white solid
存储:-20°C
Activity (short version):SRPK1 inhibitor
Function / Pharmacology:SPHINX31 is a potent (IC50 = 5.9 nM) and selective inhibitor of serine/arginine-rich protein kinase 1 (SRPK1), a splice factor kinase involved in VEGF-A isoform formation and other alternative splicing events.1 It displayed antiangiogenic effects in a mouse model of choroidal neovascularization1 a rat model of diabetic retinopathy2. SPHINX31 exhibited antitumor and synergistic (with cisplatin) effects in extranodal lymphoma cells.3 It was able to change splicing of programmed cell death receptor 1 (PD-1) to produce a more soluble form that prevented T cell exhaustion in a cancer model.4 It corrected BIN1, MCL-1, and BCL2 splicing errors in cholangiocarcinoma cells resulting in apoptosis of cancer cells.5
分子式:C27H24F3N5O2
分子量:507.52
溶剂:DMSO (15 mg/ml with warming)
性状:Off-white solid
存储:-20°C
Activity (short version):SRPK1 inhibitor
Function / Pharmacology:SPHINX31 is a potent (IC50 = 5.9 nM) and selective inhibitor of serine/arginine-rich protein kinase 1 (SRPK1), a splice factor kinase involved in VEGF-A isoform formation and other alternative splicing events.1 It displayed antiangiogenic effects in a mouse model of choroidal neovascularization1 a rat model of diabetic retinopathy2. SPHINX31 exhibited antitumor and synergistic (with cisplatin) effects in extranodal lymphoma cells.3 It was able to change splicing of programmed cell death receptor 1 (PD-1) to produce a more soluble form that prevented T cell exhaustion in a cancer model.4 It corrected BIN1, MCL-1, and BCL2 splicing errors in cholangiocarcinoma cells resulting in apoptosis of cancer cells.5