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Icilin
- 英文名称：Icilin
- 品牌：WYTSCI
- 产地：进口
- 型号：1MG
- 货号：WT-AY-B11192
- cas：36945-98-9
- 价格： ￥1/mg
- 发布日期： 2025-04-10
- 更新日期： 2025-05-23
产品详请
| 产地 | 进口 |
| 品牌 | WYTSCI |
| 货号 | WT-AY-B11192 |
| 用途 | 科研检测 |
| 英文名称 | Icilin |
| 包装规格 | 1MG |
| CAS编号 | 36945-98-9 |
| 别名 | Icilin |
| 纯度 | 98+% |
| 分子式 | |
| 是否进口 | 是 |
纯度:>98% by TLC [5% methanol in methylene chloride; Rf = 0.40]
分子式:C16H13N3O4
分子量:311.29
溶剂:DMSO (25 mg/ml)
性状:Yellow solid
存储:-20°C
Activity (short version):TRPM8 inhibitor
Function / Pharmacology:Icilin is an agonist of cold-sensitive TRP channels with 2.5-fold greater efficacy and 200-fold greater potency than menthol (EC50 = 0.36 μM for CRM1, rat orthologue of TRPM8).1 Agonist at TRPM8 (EC50 = 0.2 μM)2 and ANKTM1(TRPA1)3. Agonist effects require Ca2+ and are pH dependent.2,4 Icilin induced G1 arrest in PC-3 prostate cancer cells without cell death.5
分子式:C16H13N3O4
分子量:311.29
溶剂:DMSO (25 mg/ml)
性状:Yellow solid
存储:-20°C
Activity (short version):TRPM8 inhibitor
Function / Pharmacology:Icilin is an agonist of cold-sensitive TRP channels with 2.5-fold greater efficacy and 200-fold greater potency than menthol (EC50 = 0.36 μM for CRM1, rat orthologue of TRPM8).1 Agonist at TRPM8 (EC50 = 0.2 μM)2 and ANKTM1(TRPA1)3. Agonist effects require Ca2+ and are pH dependent.2,4 Icilin induced G1 arrest in PC-3 prostate cancer cells without cell death.5
