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SLB1122168
- 英文名称:SLB1122168
- 品牌:WYTSCI
- 产地:进口
- 型号:1MG
- 货号:WT-AY-B11196
- cas:2999629-17-1
- 价格: ¥1/mg
- 发布日期: 2025-04-10
- 更新日期: 2025-05-12
产品详请
产地 | 进口 |
品牌 | WYTSCI |
货号 | WT-AY-B11196 |
用途 | 科研检测 |
英文名称 | SLB1122168 |
包装规格 | 1MG |
CAS编号 | 2999629-17-1 |
别名 | SLB1122168 |
纯度 | 98+% |
分子式 | |
是否进口 | 是 |
纯度:>98% by HPLC;NMR (Conforms)
分子式:C22H35N3O·HCl
分子量:394
溶剂:DMSO (40 mg/ml); Water (10 mg/ml with warming)
性状:Off-white solid
存储:-20°C
Activity (short version):Spns2 inhibitor
Function / Pharmacology:SLB1122168 is a potent (IC50 = 94 nM) second generation sphingosine-1-phosphate transporter Spinster Homolog 2 (Spns2) inhibitor. In vivo, it significantly reduced circulating lymphocyte counts but did not reduce plasma sphigosine-1-phosphate levels as with the first generation inhibitor SLF1081851 (Focus Cat# 10-4395). Spns2 inhibitors represent potential alternative immunomodulatory agents to S1P receptor agonists as they are able in induce lymphopenia without drastic changes to systemic S1P levels or stimulating the S1P1-5 signaling pathway.
分子式:C22H35N3O·HCl
分子量:394
溶剂:DMSO (40 mg/ml); Water (10 mg/ml with warming)
性状:Off-white solid
存储:-20°C
Activity (short version):Spns2 inhibitor
Function / Pharmacology:SLB1122168 is a potent (IC50 = 94 nM) second generation sphingosine-1-phosphate transporter Spinster Homolog 2 (Spns2) inhibitor. In vivo, it significantly reduced circulating lymphocyte counts but did not reduce plasma sphigosine-1-phosphate levels as with the first generation inhibitor SLF1081851 (Focus Cat# 10-4395). Spns2 inhibitors represent potential alternative immunomodulatory agents to S1P receptor agonists as they are able in induce lymphopenia without drastic changes to systemic S1P levels or stimulating the S1P1-5 signaling pathway.