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SLB1122168
- 英文名称：SLB1122168
- 品牌：WYTSCI
- 产地：进口
- 型号：1MG
- 货号：WT-AY-B11196
- cas：2999629-17-1
- 价格： ￥1/mg
- 发布日期： 2025-04-10
- 更新日期： 2025-05-23
产品详请
| 产地 | 进口 |
| 品牌 | WYTSCI |
| 货号 | WT-AY-B11196 |
| 用途 | 科研检测 |
| 英文名称 | SLB1122168 |
| 包装规格 | 1MG |
| CAS编号 | 2999629-17-1 |
| 别名 | SLB1122168 |
| 纯度 | 98+% |
| 分子式 | |
| 是否进口 | 是 |
纯度:>98% by HPLC;NMR (Conforms)
分子式:C22H35N3O·HCl
分子量:394
溶剂:DMSO (40 mg/ml); Water (10 mg/ml with warming)
性状:Off-white solid
存储:-20°C
Activity (short version):Spns2 inhibitor
Function / Pharmacology:SLB1122168 is a potent (IC50 = 94 nM) second generation sphingosine-1-phosphate transporter Spinster Homolog 2 (Spns2) inhibitor. In vivo, it significantly reduced circulating lymphocyte counts but did not reduce plasma sphigosine-1-phosphate levels as with the first generation inhibitor SLF1081851 (Focus Cat# 10-4395). Spns2 inhibitors represent potential alternative immunomodulatory agents to S1P receptor agonists as they are able in induce lymphopenia without drastic changes to systemic S1P levels or stimulating the S1P1-5 signaling pathway.
分子式:C22H35N3O·HCl
分子量:394
溶剂:DMSO (40 mg/ml); Water (10 mg/ml with warming)
性状:Off-white solid
存储:-20°C
Activity (short version):Spns2 inhibitor
Function / Pharmacology:SLB1122168 is a potent (IC50 = 94 nM) second generation sphingosine-1-phosphate transporter Spinster Homolog 2 (Spns2) inhibitor. In vivo, it significantly reduced circulating lymphocyte counts but did not reduce plasma sphigosine-1-phosphate levels as with the first generation inhibitor SLF1081851 (Focus Cat# 10-4395). Spns2 inhibitors represent potential alternative immunomodulatory agents to S1P receptor agonists as they are able in induce lymphopenia without drastic changes to systemic S1P levels or stimulating the S1P1-5 signaling pathway.
