纯度:99% by HPLC,;NMR (Conforms)
分子式:C32H31BrN2O2
分子量:555.50
溶剂:DMSO (10 mg/ml)
性状:White solid
存储:RT
Activity (short version):Antituberculosis / SARS-CoV2 3CLpro inhibitor
Function / Pharmacology:Bedaquiline is a clinically useful antituberculosis agent that is active (MIC’s 0.030 to 0.120 μg/mL) against multi-drug resistant strains.1 It interferes with mycobacterial energy metabolism via binding to the oligomeric subunit c (AtpE)2 and subunit ?3 of ATP synthase inhibiting ATP production.4 Bedaquiline has recently been found to be an inhibitor (IC50 = 18.7 μM) of the SARS-CoV-2 main protease, 3CLpro.5