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CCT251236
- 英文名称:CCT251236
- 品牌:WYTSCI
- 产地:进口
- 型号:1MG
- 货号:WT-AY-B11201
- cas:1693731-40-6
- 价格: ¥1/mg
- 发布日期: 2025-04-10
- 更新日期: 2025-05-23
产品详请
产地 | 进口 |
品牌 | WYTSCI |
货号 | WT-AY-B11201 |
用途 | 科研检测 |
英文名称 | CCT251236 |
包装规格 | 1MG |
CAS编号 | 1693731-40-6 |
别名 | CCT251236 |
纯度 | 98+% |
分子式 | |
是否进口 | 是 |
纯度:98% by HPLC;NMR (Conforms)
分子式:C32H32N4O5
分子量:552.63
溶剂:DMSO (5 mg/ml)
性状:Off-white/beige solid
存储:-20°C
Activity (short version):HSF stress pathway inhibitor
Function / Pharmacology:Inhibitor of the Heat Shock Transcription Factor 1 (HSF1) stress pathway (IC50 = 19 nM Inhibition HSF-1 mediated HSP72 induction, IC50 = 40 nM HSPA1A induction).1 It displayed efficacy in a human ovarian carcinoma xenograft mouse model (SK-OV 3 cells) and inhibited migration of WM266.4 melanoma cells @ 100 nM. CCT251236 showed high affinity for the protein pirin (Ki = 28 nM), but this target was not shown conclusively to be the cause of the anticancer activity. It also showed efficacy in vitro against primary patient-derived myeloma cells and H929 human myeloma xenograft models.2
分子式:C32H32N4O5
分子量:552.63
溶剂:DMSO (5 mg/ml)
性状:Off-white/beige solid
存储:-20°C
Activity (short version):HSF stress pathway inhibitor
Function / Pharmacology:Inhibitor of the Heat Shock Transcription Factor 1 (HSF1) stress pathway (IC50 = 19 nM Inhibition HSF-1 mediated HSP72 induction, IC50 = 40 nM HSPA1A induction).1 It displayed efficacy in a human ovarian carcinoma xenograft mouse model (SK-OV 3 cells) and inhibited migration of WM266.4 melanoma cells @ 100 nM. CCT251236 showed high affinity for the protein pirin (Ki = 28 nM), but this target was not shown conclusively to be the cause of the anticancer activity. It also showed efficacy in vitro against primary patient-derived myeloma cells and H929 human myeloma xenograft models.2