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CCT251236
  • 英文名称:CCT251236
  • 品牌:WYTSCI
  • 产地:进口
  • 型号:1MG
  • 货号:WT-AY-B11201
  • cas:1693731-40-6
  • 价格: ¥1/mg
  • 发布日期: 2025-04-10
  • 更新日期: 2025-05-12
产品详请
产地 进口
品牌 WYTSCI
货号 WT-AY-B11201
用途 科研检测
英文名称 CCT251236
包装规格 1MG
CAS编号 1693731-40-6
别名 CCT251236
纯度 98+%
分子式
是否进口
纯度:98% by HPLC;NMR (Conforms)
分子式:C32H32N4O5
分子量:552.63
溶剂:DMSO (5 mg/ml)
性状:Off-white/beige solid
存储:-20°C
Activity (short version):HSF stress pathway inhibitor
Function / Pharmacology:Inhibitor of the Heat Shock Transcription Factor 1 (HSF1) stress pathway (IC50 = 19 nM Inhibition HSF-1 mediated HSP72 induction, IC50 = 40 nM HSPA1A induction).1 It displayed efficacy in a human ovarian carcinoma xenograft mouse model (SK-OV 3 cells) and inhibited migration of WM266.4 melanoma cells @ 100 nM. CCT251236 showed high affinity for the protein pirin (Ki = 28 nM), but this target was not shown conclusively to be the cause of the anticancer activity. It also showed efficacy in vitro against primary patient-derived myeloma cells and H929 human myeloma xenograft models.2
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