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SBI-553
- 英文名称：SBI-553
- 品牌：WYTSCI
- 产地：进口
- 型号：1MG
- 货号：WT-AY-B11212
- cas：1849603-72-0
- 价格： ￥1/mg
- 发布日期： 2025-04-10
- 更新日期： 2025-05-23
产品详请
| 产地 | 进口 |
| 品牌 | WYTSCI |
| 货号 | WT-AY-B11212 |
| 用途 | 科研检测 |
| 英文名称 | SBI-553 |
| 包装规格 | 1MG |
| CAS编号 | 1849603-72-0 |
| 别名 | SBI-553 |
| 纯度 | 98+% |
| 分子式 | |
| 是否进口 | 是 |
纯度:>98% by HPLC;NMR (Conforms)
分子式:C26H31FN4O2
分子量:450.56
溶剂:DMSO (12 mg/ml)
性状:Pale yellow solid
存储:-20°C
Activity (short version):?-Arrestin-biased NTSR1 modulator
Function / Pharmacology:SBI-553 is a potent, brain penetrant, and orally bioavailable allosteric modulator of neurotensin receptor 1 (NTSR1; EC50 = 340 nM)).1 It acts as a ?-Arrestin-biased agonist and selectively antagonizes G protein signaling conferring profound ?-Arrestin bias towards the endogenous ligand.2,3 SBI-553 displayed efficacy in mouse models of psychostimulant abuse without the characteristic undesirable side effects of unbiased NTSR1 agonism. This functionally selective modulation of NTSR1 may be a new therapeutic approach to treating psychostimulant abuse and other chemical and behavioral addictions.
分子式:C26H31FN4O2
分子量:450.56
溶剂:DMSO (12 mg/ml)
性状:Pale yellow solid
存储:-20°C
Activity (short version):?-Arrestin-biased NTSR1 modulator
Function / Pharmacology:SBI-553 is a potent, brain penetrant, and orally bioavailable allosteric modulator of neurotensin receptor 1 (NTSR1; EC50 = 340 nM)).1 It acts as a ?-Arrestin-biased agonist and selectively antagonizes G protein signaling conferring profound ?-Arrestin bias towards the endogenous ligand.2,3 SBI-553 displayed efficacy in mouse models of psychostimulant abuse without the characteristic undesirable side effects of unbiased NTSR1 agonism. This functionally selective modulation of NTSR1 may be a new therapeutic approach to treating psychostimulant abuse and other chemical and behavioral addictions.
